methyl 7-formyl-4,6-dimethoxy-benzothiophene-2-carboxylate

Base Information

• Chemical Name: methyl 7-formyl-4,6-dimethoxy-benzothiophene-2-carboxylate
• CAS No.: 112664-43-4
• Molecular Formula: C13H12O5S
• Mol file: 112664-43-4.mol

Synonyms:

Chemical Property of methyl 7-formyl-4,6-dimethoxy-benzothiophene-2-carboxylate

Chemical Property:

• Vapor Pressure: 6.13E-09mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 7-formyl-4,6-dimethoxy-benzothiophene-2-carboxylate

There total 3 articles about methyl 7-formyl-4,6-dimethoxy-benzothiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethoxybenzenethiol (19689-66-8) → methyl 7-formyl-4,6-dimethoxy-2-benzothiophenecarboxylate (112664-43-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) K₂CO₃, KI / 1.) DMSO, RT, 30 min, 2.) DMSO, RT, 0.5 h

2: 1.) POCl₃ / 1.) 0.5 h, 2.) 60 deg C, 1.5 h

3: methanol; diethyl ether

With potassium carbonate; potassium iodide; trichlorophosphate; In methanol; diethyl ether;

DOI:10.3987/R-1987-10-2717

Reference yield:

3,5-dimethoxyphenylthioacetic acid (112664-33-2) → methyl 7-formyl-4,6-dimethoxy-2-benzothiophenecarboxylate (112664-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) POCl₃ / 1.) 0.5 h, 2.) 60 deg C, 1.5 h

2: methanol; diethyl ether

With trichlorophosphate; In methanol; diethyl ether;

DOI:10.3987/R-1987-10-2717

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 7-formyl-4,6-dimethoxy-2-benzothiophenecarboxylic acid (112664-42-3) → methyl 7-formyl-4,6-dimethoxy-2-benzothiophenecarboxylate (112664-43-4)

Guidance literature:

In methanol; diethyl ether;

DOI:10.3987/R-1987-10-2717

upstream raw materials:

diazomethane

7-formyl-4,6-dimethoxy-2-benzothiophenecarboxylic acid

3,5-dimethoxybenzenethiol

3,5-dimethoxyphenylthioacetic acid

Refernces