N-(2,2-Dimethyltetrahydro-2H-thiopyran-4-yl)-1-piperidineacetanilide

Base Information

Chemical Name:N-(2,2-Dimethyltetrahydro-2H-thiopyran-4-yl)-1-piperidineacetanilide
CAS No.:78028-49-6
Molecular Formula:C₂₀H₃₀N₂OS
Molecular Weight:346.537
Hs Code.:
DSSTox Substance ID:DTXSID40999282
Nikkaji Number:J62.701A

Synonyms:BRN 5290954;NIOSH/TM3530000;TM35300000;1-Piperidineacetamide, N-(2,2-dimethyl-2H-tetrahydrothiopyran-4-yl)-N-phenyl-;N-(2,2-Dimethyl-2H-tetrahydrothiopyran-4-yl)-N-phenyl-1-piperidineacetamide;78028-49-6;N-(2,2-Dimethyltetrahydro-2H-thiopyran-4-yl)-1-piperidineacetanilide;1-Piperidineacetanilide, N-(2,2-dimethyltetrahydro-2H-thiopyran-4-yl)-;DTXSID40999282;C20-H30-N2-O-S;LS-113955;LS-114069;N-(2,2-DIMETHYLTHIAN-4-YL)-N-PHENYL-2-(PIPERIDIN-1-YL)ACETAMIDE;N-(2,2-Dimethyltetrahydro-2H-thiopyran-4-yl)-N-phenyl-1-piperidineacetamide

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2,2-Dimethyltetrahydro-2H-thiopyran-4-yl)-1-piperidineacetanilide

Chemical Property:

Vapor Pressure:6.04E-09mmHg at 25°C
Boiling Point:468.3°Cat760mmHg
Flash Point:237°C
Density:1.1g/cm³
XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:346.20788476
Heavy Atom Count:24
Complexity:414

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CC(CCS1)N(C2=CC=CC=C2)C(=O)CN3CCCCC3)C

Technology Process of N-(2,2-Dimethyltetrahydro-2H-thiopyran-4-yl)-1-piperidineacetanilide

There total 5 articles about N-(2,2-Dimethyltetrahydro-2H-thiopyran-4-yl)-1-piperidineacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.4%

: 110-89-4
piperidine

: 78028-35-0
2-Chloro-N-(2,2-dimethyl-tetrahydro-thiopyran-4-yl)-N-phenyl-acetamide

: 78028-49-6
N-(2,2-Dimethyl-tetrahydro-thiopyran-4-yl)-N-phenyl-2-piperidin-1-yl-acetamide

Guidance literature:: In benzene; for 12h; Ambient temperature;
DOI:10.1007/BF00758461

Reference yield:

: 2323-13-9
2,2-dimethylthian-4-one

: 78028-49-6
N-(2,2-Dimethyl-tetrahydro-thiopyran-4-yl)-N-phenyl-2-piperidin-1-yl-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / p-toluenesulfonic acid / benzene / Heating

2: 90 percent / NaBH₄ / methanol / 0.5 h / 20 °C

3: 61 percent / triethylamine / benzene / 1.) cooling, 30 min, 2.) 20 deg C, 2 h

4: 55.4 percent / benzene / 12 h / Ambient temperature

With sodium tetrahydroborate; toluene-4-sulfonic acid; triethylamine; In methanol; benzene;
DOI:10.1007/BF00758461

Reference yield:

: 78028-32-7
(2,2-Dimethyl-tetrahydro-thiopyran-4-yl)-phenyl-amine

: 78028-49-6
N-(2,2-Dimethyl-tetrahydro-thiopyran-4-yl)-N-phenyl-2-piperidin-1-yl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / triethylamine / benzene / 1.) cooling, 30 min, 2.) 20 deg C, 2 h

2: 55.4 percent / benzene / 12 h / Ambient temperature

With triethylamine; In benzene;
DOI:10.1007/BF00758461