Technology Process of 3,3-dimethyl-1-phenyl-1,3-dihydro-2H-indole-2-thione
There total 3 articles about 3,3-dimethyl-1-phenyl-1,3-dihydro-2H-indole-2-thione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Lawessons reagent; toluene-4-sulfonic acid;
In
toluene;
at 110 ℃;
for 1.5h;
Inert atmosphere;
DOI:10.1002/anie.201901619
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
2: copper(l) iodide; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere
3: toluene-4-sulfonic acid; Lawessons reagent / toluene / 1.5 h / 110 °C / Inert atmosphere
With
Lawessons reagent; copper(l) iodide; potassium carbonate; toluene-4-sulfonic acid; trans-N,N'-dimethylcyclohexane-1,2-diamine; trifluoroacetic acid;
In
1,4-dioxane; dichloromethane; toluene;
DOI:10.1002/anie.201901619
- Guidance literature:
-
Multi-step reaction with 2 steps
1: copper(l) iodide; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere
2: toluene-4-sulfonic acid; Lawessons reagent / toluene / 1.5 h / 110 °C / Inert atmosphere
With
Lawessons reagent; copper(l) iodide; potassium carbonate; toluene-4-sulfonic acid; trans-N,N'-dimethylcyclohexane-1,2-diamine;
In
1,4-dioxane; toluene;
DOI:10.1002/anie.201901619
