(2-Cyclopropyl-2-oxoethyl)triphenyl-phosphoniuM BroMide

Base Information

• Chemical Name: (2-Cyclopropyl-2-oxoethyl)triphenyl-phosphoniuM BroMide
• CAS No.: 112849-15-7
• Molecular Formula: C23H22OP.Br
• Molecular Weight: 425.305
• Mol file: 112849-15-7.mol

Synonyms:cyclopropylcarbonylmethyltriphenylphosphonium bromide;(2-Cyclopropyl-2-oxoethyl)triphenyl-phosphonium Bromide;Phosphonium,(2-cyclopropyl-2-oxoethyl)triphenyl-,bromide;

Chemical Property of (2-Cyclopropyl-2-oxoethyl)triphenyl-phosphoniuM BroMide

Chemical Property:

• PSA: 30.66000
• LogP: 0.96360
• Solubility.: Methanol, Water

Purity/Quality:

99.90% ^*data from raw suppliers

(2-Cyclopropyl-2-oxoethyl)triphenyl-phosphoniumBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant in the preparation of Vitamin D2 (V676040) derivatives.

Technology Process of (2-Cyclopropyl-2-oxoethyl)triphenyl-phosphoniuM BroMide

There total 3 articles about (2-Cyclopropyl-2-oxoethyl)triphenyl-phosphoniuM BroMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-bromo-1-cyclopropylethan-1-one (69267-75-0) + triphenylphosphine (603-35-0) → (2-cyclopropyl-2-oxoethyl) (triphenyl)phosphonium bromide (112849-15-7)

Guidance literature:

DOI:10.1016/S0040-4020(01)86903-9

Reference yield:

Cyclopropyl methyl ketone (765-43-5) → (2-cyclopropyl-2-oxoethyl) (triphenyl)phosphonium bromide (112849-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / bromine / methanol / 0.5 h / Ambient temperature

2: 84 percent

With bromine; In methanol;

DOI:10.1016/S0040-4020(01)86903-9

Reference yield:

→ (2-cyclopropyl-2-oxoethyl) (triphenyl)phosphonium bromide (112849-15-7)

Guidance literature:

upstream raw materials:

2-bromo-1-cyclopropylethan-1-one

triphenylphosphine

Cyclopropyl methyl ketone

Downstream raw materials:

20(R),3(R)-(tert-butyldimethylsilyloxy)-20-(3'-cyclopropyl-3'-oxoprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10⁽¹⁹⁾-triene

(1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'ξ-cyclopropyl-3'-hydroxypropyl)-9,10-secopregna-5(E),7(E),10(19)-triene

1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3’-cyclopropyl-3’-oxypropyl)-9,10-secopregna-5(E),7(E),10(19)-triene

20(R)-(3'(R)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-1(S),3(R)-dihydroxy-9,10-secopregna-5(Z),7(E),10⁽¹⁹⁾-triene

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