Benzenemethanesulfenyl chloride, a-phenyl-a-(trifluoromethyl)-

Base Information

• Chemical Name: Benzenemethanesulfenyl chloride, a-phenyl-a-(trifluoromethyl)-
• CAS No.: 112881-92-2
• Molecular Formula: C14H10ClF3S
• Molecular Weight: 302.748
• Mol file: 112881-92-2.mol

Synonyms:

Chemical Property of Benzenemethanesulfenyl chloride, a-phenyl-a-(trifluoromethyl)-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanesulfenyl chloride, a-phenyl-a-(trifluoromethyl)-

There total 5 articles about Benzenemethanesulfenyl chloride, a-phenyl-a-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,2,2-Trifluoro-1,1-diphenylethanethiol (112881-91-1) → 2,2,2-trifluoro-1,1-diphenylethane-sulfenyl chloride (112881-92-2)

Guidance literature:

With sulfuryl dichloride; In diethyl ether; for 0.25h; Ambient temperature;

DOI:10.1055/s-1987-28045

Reference yield: 95.0%

N-<<(1S,2R,3R,5S)-2,6,6-trimethylbicyclo<3.1.1>hept-3-yl>methyl>-2,2,2-trifluoro-1,1-diphenylethanesulfenamide (138036-47-2) → 2,2,2-trifluoro-1,1-diphenylethane-sulfenyl chloride (112881-92-2) + (+)-3-(aminomethyl)pinane hydrochloride (57357-84-3)

Guidance literature:

With hydrogenchloride; In diethyl ether; Product distribution; Ambient temperature; other in the same manner protected amines investigated;

DOI:10.1016/S0040-4020(01)91009-9

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 2,2,2-trifluoro-1,1-diphenylethane-sulfenyl chloride (112881-92-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) Mg / 1.) ether, 2.) reflux, 1 h

2: 1.) NaH / 1.) ether, room temp., 1 h, 2.) room temp., 70 h

3: 96 percent / H₂S, p-TsOH / various solvent(s) / 1 h / 60 °C

4: 96 percent / sulfuryl chloride / diethyl ether / 0.25 h / Ambient temperature

With sulfuryl dichloride; hydrogen sulfide; sodium hydride; toluene-4-sulfonic acid; magnesium; In diethyl ether;

DOI:10.1055/s-1987-28045

upstream raw materials:

N-<<(1S,2R,3R,5S)-2,6,6-trimethylbicyclo<3.1.1>hept-3-yl>methyl>-2,2,2-trifluoro-1,1-diphenylethanesulfenamide

2,2,2-Trifluoro-1,1-diphenylethanethiol

bromobenzene

1,1-diphenyl-2,2,2-trifluoroethanol

Downstream raw materials:

N,N-bis(2-methoxyethyl)-2,2,2-trifluoro-1,1-diphenylethanesulfenamide

C₂₀H₁₄F₃NO₃S

2,2,2-Trifluoro-1,1-diphenyl-ethanesulfonic acid (1S,2R,3R,5S,6R,7R)-6-(2,2,2-trifluoro-1,1-diphenyl-ethanesulfonyloxy)-4,8-dioxa-tricyclo[5.1.0.0^3,5]oct-2-yl ester

2,2,2-Trifluoro-1,1-diphenyl-ethanesulfinic acid (1S,2R,3R,5S,6R,7R)-6-(2,2,2-trifluoro-1,1-diphenyl-ethanesulfinyloxy)-4,8-dioxa-tricyclo[5.1.0.0^3,5]oct-2-yl ester