L-Glutamic acid, N-[4-[[[1,4-dihydro-2-(hydroxymethyl)-4-oxo-6-quinazolinyl]methyl]methyl amino]benzoyl]-

Base Information

• Chemical Name: L-Glutamic acid, N-[4-[[[1,4-dihydro-2-(hydroxymethyl)-4-oxo-6-quinazolinyl]methyl]methyl amino]benzoyl]-
• CAS No.: 112887-90-8
• Molecular Formula: C₂₃H₂₄N₄O₇
• Molecular Weight: 468.466
• Mol file: 112887-90-8.mol

Synonyms:

Chemical Property of L-Glutamic acid, N-[4-[[[1,4-dihydro-2-(hydroxymethyl)-4-oxo-6-quinazolinyl]methyl]methyl amino]benzoyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Glutamic acid, N-[4-[[[1,4-dihydro-2-(hydroxymethyl)-4-oxo-6-quinazolinyl]methyl]methyl amino]benzoyl]-

There total 4 articles about L-Glutamic acid, N-[4-[[[1,4-dihydro-2-(hydroxymethyl)-4-oxo-6-quinazolinyl]methyl]methyl amino]benzoyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

(S)-2-{4-[(2-Acetoxymethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid diethyl ester → (S)-2-{4-[(2-Hydroxymethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid (112887-90-8)

Guidance literature:

With sodium hydroxide; for 4h; Ambient temperature;

DOI:10.1021/jm00173a024

Reference yield:

diethyl N-<4-(methylamino)benzoyl>-L-glutamate (2378-95-2) → (S)-2-{4-[(2-Hydroxymethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid (112887-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: CaCO₃ / dimethylformamide / 24 h / 50 °C

2: 23 percent / 1 N aq. NaOH / 4 h / Ambient temperature

With sodium hydroxide; calcium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm00173a024

Reference yield:

Acetic acid 6-bromomethyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester (112889-01-7) → (S)-2-{4-[(2-Hydroxymethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid (112887-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: CaCO₃ / dimethylformamide / 24 h / 50 °C

2: 23 percent / 1 N aq. NaOH / 4 h / Ambient temperature

With sodium hydroxide; calcium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm00173a024

upstream raw materials:

diethyl N-<4-(methylamino)benzoyl>-L-glutamate

Acetic acid 6-bromomethyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

Acetic acid 6-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester