Chemical Property of Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide
Chemical Property:
- Vapor Pressure:1.17E-09mmHg at 25°C
- Boiling Point:487.6°C at 760 mmHg
- PKA:6.23±0.42(Predicted)
- Flash Point:248.7°C
- PSA：103.79000
- Density:1.64
- LogP:1.44240
- Solubility.:Limited solubility
- XLogP3:1.2
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:1
- Exact Mass:279.09675391
- Heavy Atom Count:20
- Complexity:370
- Purity/Quality:
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99%, *data from raw suppliers
NSC207895(XI-006) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-]
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Description
NSC 207895 is an inhibitor of the p53-binding protein MDMX. It decreases MDMX promoter activity in a reporter assay using HT-1080 cells in a concentration-dependent manner. NSC 207895 (5 μmol/L) decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX. It also increases the expression of the pro-apoptotic genes PUMA, Bax, and PIG3. NSC 207895 (5 μmol/L) induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner. It also induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC50s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC50s = 3,690-5,416 and 2,143 nM, respectively).
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Uses
NSC-207895 is an anticancer agent and p53 activator. NSC 207895 decreases the expression of MDMX but also induced the expression of MDM2. It can also be used in pharmacological activity and therapeutic use of reviving antibiotics in relation to prepared efflux pump inhibitors that interact with AcrA, membrane fusion protein of AcrAB-TolC multidrug efflux pump.
