Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-[(phenyl sulfinyl)methyl]-

Base Information

Chemical Name:Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-[(phenyl sulfinyl)methyl]-
CAS No.:112988-36-0
Molecular Formula:C18H12F6N2O3S
Molecular Weight:450.361
Hs Code.:

Synonyms:

Suppliers and Price of Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-[(phenyl sulfinyl)methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-[(phenyl sulfinyl)methyl]-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-[(phenyl sulfinyl)methyl]-

There total 4 articles about Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-[(phenyl sulfinyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 90356-35-7
4-cyano-3-trifluoromethyl-N-(2-hydroxy-3-phenylthio-2-trifluoromethylpropionyl)aniline

: 112988-36-0
2-Benzenesulfinylmethyl-N-(4-cyano-3-trifluoromethyl-phenyl)-3,3,3-trifluoro-2-hydroxy-propionamide

Guidance literature:: With sodium periodate; In methanol; water; for 48h; Ambient temperature;
DOI:10.1021/jm00400a011

Reference yield:

: 34509-09-6
1,1,1-trifluoro-3-(phenylthio)propan-2-one

: 112988-36-0
2-Benzenesulfinylmethyl-N-(4-cyano-3-trifluoromethyl-phenyl)-3,3,3-trifluoro-2-hydroxy-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂SO₄ / H₂O / 16 h / Ambient temperature

2: conc. HCl, glacial AcOH / 24 h / Heating

3: 1.) SOCl₂, N,N-dimethylacetamide / 1.) -15 deg C, 15 min, 2.) -15 deg C, 15 min; room temperature, 16 h

4: 73 percent / sodium metaperiodate / H₂O; methanol / 48 h / Ambient temperature

With hydrogenchloride; sodium periodate; thionyl chloride; N,N-dimethyl acetamide; sulfuric acid; acetic acid; In methanol; water;
DOI:10.1021/jm00400a011

Reference yield:

: 90357-42-9
3-(phenylthio)-1,1,1-trifluoropropan-2-one cyanohydrin

: 112988-36-0
2-Benzenesulfinylmethyl-N-(4-cyano-3-trifluoromethyl-phenyl)-3,3,3-trifluoro-2-hydroxy-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: conc. HCl, glacial AcOH / 24 h / Heating

2: 1.) SOCl₂, N,N-dimethylacetamide / 1.) -15 deg C, 15 min, 2.) -15 deg C, 15 min; room temperature, 16 h

3: 73 percent / sodium metaperiodate / H₂O; methanol / 48 h / Ambient temperature

With hydrogenchloride; sodium periodate; thionyl chloride; N,N-dimethyl acetamide; acetic acid; In methanol; water;
DOI:10.1021/jm00400a011