Spiro(piperidine-4,4'(1'H)-quinazolin)-2'(3'H)-one, 1-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-3'-methyl-

Base Information

Chemical Name:Spiro(piperidine-4,4'(1'H)-quinazolin)-2'(3'H)-one, 1-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-3'-methyl-
CAS No.:85732-33-8
Molecular Formula:C₂₃H₂₉N₃O₄
Molecular Weight:411.501
Hs Code.:
DSSTox Substance ID:DTXSID001006350

Synonyms:85732-33-8;Spiro(piperidine-4,4'(1'H)-quinazolin)-2'(3'H)-one, 1-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-3'-methyl-;DTXSID001006350;LS-146324;1-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]-3'-methyl-3'H-spiro[piperidine-4,4'-quinazolin]-2'-ol

Suppliers and Price of Spiro(piperidine-4,4'(1'H)-quinazolin)-2'(3'H)-one, 1-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-3'-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Spiro(piperidine-4,4'(1'H)-quinazolin)-2'(3'H)-one, 1-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-3'-methyl-

Chemical Property:

Boiling Point:638.6°Cat760mmHg
Flash Point:340°C
Density:1.29g/cm³
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:411.21580641
Heavy Atom Count:30
Complexity:595

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=O)NC2=CC=CC=C2C13CCN(CC3)CC(C4=CC(=C(C=C4)OC)OC)O

Technology Process of Spiro(piperidine-4,4'(1'H)-quinazolin)-2'(3'H)-one, 1-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-3'-methyl-

There total 5 articles about Spiro(piperidine-4,4'(1'H)-quinazolin)-2'(3'H)-one, 1-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-3'-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121061-01-6
1-benzyl-6'-chloro-5,6-dihydro-3-iodo-3'-methyl-spiro-2'(1'H)-one

: 85732-33-8
1-<2-(3,4-dimethoxyphenyl)-2-hydroxyethyl>-3'-methyl-spiro-2'(1'H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 98.8 percent / H₂, triethylamine / 10percent Pd-C / H₂O; methanol / 16 h / 40 °C

2: triethylamine (TEA) / ethanol / 34 h / Ambient temperature

3: NaBH₄ / ethanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; water;

Reference yield:

: 107191-02-6
1-benzyl-4-<2-(N-methylcarbamoylamino)-5-chlorophenyl>-1,2,5,6-tetrahydropyridine

: 85732-33-8
1-<2-(3,4-dimethoxyphenyl)-2-hydroxyethyl>-3'-methyl-spiro-2'(1'H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 83.4 percent / I₂, NaI, 10percent aq. NaHCO₃ / H₂O; CH₂Cl₂ / 2 h / Ambient temperature

2: 98.8 percent / H₂, triethylamine / 10percent Pd-C / H₂O; methanol / 16 h / 40 °C

3: triethylamine (TEA) / ethanol / 34 h / Ambient temperature

4: NaBH₄ / ethanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; iodine; sodium hydrogencarbonate; triethylamine; sodium iodide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water;