1,2,3,4-Tetrahydro-1,2-bis(3-fluorophenyl)-6-methoxyisoquinoline

Base Information

Chemical Name:1,2,3,4-Tetrahydro-1,2-bis(3-fluorophenyl)-6-methoxyisoquinoline
CAS No.:96719-68-5
Molecular Formula:C₂₂H₁₉F₂NO
Molecular Weight:351.396
Hs Code.:
DSSTox Substance ID:DTXSID40914359

Synonyms:1,2,3,4-Tetrahydro-1,2-bis(3-fluorophenyl)-6-methoxyisoquinoline;96719-68-5;Isoquinoline, 1,2,3,4-tetrahydro-1,2-bis(3-fluorophenyl)-6-methoxy-;C22H19F2NO;DTXSID40914359;C22-H19-F2-N-O;1,2-BIS(3-FLUOROPHENYL)-6-METHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE;LS-85828

Suppliers and Price of 1,2,3,4-Tetrahydro-1,2-bis(3-fluorophenyl)-6-methoxyisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 1,2,3,4-Tetrahydro-1,2-bis(3-fluorophenyl)-6-methoxyisoquinoline

Chemical Property:

Vapor Pressure:1.39E-09mmHg at 25°C
Boiling Point:485.6°Cat760mmHg
Flash Point:247.5°C
Density:1.219g/cm³
XLogP3:5.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:351.14347055
Heavy Atom Count:26
Complexity:461

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C(N(CC2)C3=CC(=CC=C3)F)C4=CC(=CC=C4)F

Technology Process of 1,2,3,4-Tetrahydro-1,2-bis(3-fluorophenyl)-6-methoxyisoquinoline

There total 5 articles about 1,2,3,4-Tetrahydro-1,2-bis(3-fluorophenyl)-6-methoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1798-09-0
m-methoxyphenylacetic acid

: 96719-68-5
1,2-Bis-(3-fluoro-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / benzene / 1 h / Heating

2: diethyl ether / Ambient temperature

3: 81 percent / LAH / dioxane; diethyl ether

4: 1.) SOCl₂ / 1.) benzene, reflux, 2.) ether, r.t.

5: 1.) POCl₃, 2.) KI / 1.) reflux, 2.) H₂O

6: NaBH₄ / methanol

With sodium tetrahydroborate; lithium aluminium tetrahydride; thionyl chloride; potassium iodide; trichlorophosphate; In 1,4-dioxane; methanol; diethyl ether; benzene;

Reference yield:

: 96718-73-9
3-fluoro-N-(3-methoxyphenethyl)aniline

: 96719-68-5
1,2-Bis-(3-fluoro-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) SOCl₂ / 1.) benzene, reflux, 2.) ether, r.t.

2: 1.) POCl₃, 2.) KI / 1.) reflux, 2.) H₂O

3: NaBH₄ / methanol

With sodium tetrahydroborate; thionyl chloride; potassium iodide; trichlorophosphate; In methanol;

Reference yield:

: 96718-68-2
N-(3’-fluorophenyl)-2-(3-methoxyphenyl)acetamide

: 96719-68-5
1,2-Bis-(3-fluoro-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / LAH / dioxane; diethyl ether

2: 1.) SOCl₂ / 1.) benzene, reflux, 2.) ether, r.t.

3: 1.) POCl₃, 2.) KI / 1.) reflux, 2.) H₂O

4: NaBH₄ / methanol

With sodium tetrahydroborate; lithium aluminium tetrahydride; thionyl chloride; potassium iodide; trichlorophosphate; In 1,4-dioxane; methanol; diethyl ether;