Methyl 1-(4-methoxybenzene-1-sulfonyl)-1H-indole-2-carboxylate

Base Information

Chemical Name:Methyl 1-(4-methoxybenzene-1-sulfonyl)-1H-indole-2-carboxylate
CAS No.:113072-27-8
Molecular Formula:C17H15NO5S
Molecular Weight:345.376
Hs Code.:
DSSTox Substance ID:DTXSID10706364
Wikidata:Q82639706

Synonyms:113072-27-8;SCHEMBL10767782;DTXSID10706364;Methyl 1-(4-methoxybenzene-1-sulfonyl)-1H-indole-2-carboxylate

Suppliers and Price of Methyl 1-(4-methoxybenzene-1-sulfonyl)-1H-indole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Methyl 1-(4-methoxybenzene-1-sulfonyl)-1H-indole-2-carboxylate

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:345.06709375
Heavy Atom Count:24
Complexity:550

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3C=C2C(=O)OC

Technology Process of Methyl 1-(4-methoxybenzene-1-sulfonyl)-1H-indole-2-carboxylate

There total 1 articles about Methyl 1-(4-methoxybenzene-1-sulfonyl)-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 113072-27-8
methyl N-(4-methoxybenzenesulfonyl)indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice

With sodium hydride; sodium hydrogencarbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.10.022

Reference yield:

: 113072-27-8
methyl N-(4-methoxybenzenesulfonyl)indole-2-carboxylate

: 334701-11-0
N-(4-methoxybenzenesulfonyl)indole-2-carboxylic acid

Guidance literature:: methyl N-(4-methoxybenzenesulfonyl)indole-2-carboxylate; With sodium hydroxide; In ethanol; water; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; Inert atmosphere;
DOI:10.1016/j.tet.2011.10.022

Reference yield:

: 113072-27-8
methyl N-(4-methoxybenzenesulfonyl)indole-2-carboxylate

: 1352536-85-6
N-(4-methoxybenzenesulfonyl)-1-methyl-3-oxo-(1H)-furo[3,4-b]indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / ethanol; water / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: thionyl chloride / toluene / 2 h / Inert atmosphere; Reflux

3.1: dichloromethane / 20 °C / Inert atmosphere

4.1: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / tetrahydrofuran / -78 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

4.3: 20 °C / Inert atmosphere

5.1: manganese(IV) oxide; acetic acid / dichloromethane / 20 °C / Inert atmosphere

With manganese(IV) oxide; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; acetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1016/j.tet.2011.10.022