10.1021/tx970134z
The research aimed to synthesize novel dithiocarbamate chelating agents to address cadmium intoxication and evaluate their effectiveness in cadmium decorporation. The study sought to develop compounds that were not only more effective but also less toxic than those previously reported. The chelating agents synthesized were disodium salts of N-glucamyl-N-dithiocarboxyl-amino acids, which included disodium N-(2,3,4,5,6-pentahydroxylhexyl)-N-dithiocarbamate-L-threoninate and disodium N-(2,3,4,5,6-pentahydroxylhexyl)-N-dithiocarbamate-L-cysteinate. These agents were found to be superior to sodium N-(4-methoxybenzyl)-D-glucamine-N-carbodithioate (MeOBGDTC) in experiments, showing greater cadmium mobilizing properties and lower toxicity. The research concluded that these new dithiocarbamates were effective in both acute and repeated exposure cadmium poisoning, with minimal impact on the concentrations of essential metal ions in the renal cortex compared to a group treated with cadmium only. The study demonstrated the potential of these novel compounds as antidotes for cadmium intoxication.
