aprinocarsen

Base Information

• Chemical Name: aprinocarsen
• CAS No.: 151879-73-1
• Molecular Formula: C196H249N68O105P19S19
• Molecular Weight: 6435.203319
• Mol file: 151879-73-1.mol

Synonyms:59: PN:US6222025 SEQID: 27 claimed sequence; Aprinocarsen; CGP 64128A;Deoxyribonucleic acid (antisense ISIS 3521); ISIS 3521; LY900003

Chemical Property of aprinocarsen

Chemical Property:

• PSA: 3183.02000
• LogP: 16.78010

Purity/Quality:

97% ^*data from raw suppliers

AFFINITAK 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Treatment of non-small cell lung cancer (antisense oligonucleotide; protein kinase C-alpha inhibitor).
• Clinical Use: Aprinocarsen is a phosphorothioate antisense agent targeted against protein kinase Cα, a protein that is implicated in malignant transformation and proliferation. It showed activity in Phase I and Phase II clinical trials against nonsmall-cell lung cancer when used in combination with cisplatin or the combination of cisplatin and gemcitabine.