(2S)-3-BroMo-N-[4-cyano-3-(trifluoroMethyl)phenyl]-2-hydroxy-2-Methyl-propanaMide

Base Information

Chemical Name:(2S)-3-BroMo-N-[4-cyano-3-(trifluoroMethyl)phenyl]-2-hydroxy-2-Methyl-propanaMide
CAS No.:113181-02-5
Molecular Formula:C12H10BrF3N2O2
Molecular Weight:351.123
Hs Code.:
Mol file:113181-02-5.mol

Synonyms:(2S)-3-Bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-propanamide;

Suppliers and Price of (2S)-3-BroMo-N-[4-cyano-3-(trifluoroMethyl)phenyl]-2-hydroxy-2-Methyl-propanaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S)-3-Bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-propanamide
10mg
$ 150.00

TRC
(2S)-3-Bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-propanamide
100mg
$ 1190.00

Medical Isotopes, Inc.
(2S)-3-Bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-propanamide
10 mg
$ 650.00

Total 2 raw suppliers

Chemical Property of (2S)-3-BroMo-N-[4-cyano-3-(trifluoroMethyl)phenyl]-2-hydroxy-2-Methyl-propanaMide

Chemical Property:

Melting Point:>130°C (dec.)
PSA：73.12000
LogP:2.73448
Storage Temp.:Refrigerator
Solubility.:Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99.90% ^*data from raw suppliers

(2S)-3-Bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-propanamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (2S)-3-Bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-propanamide is a reactant used in the preparation of hydroxy(phenylthio)propionanilides as affinity ligands for the androstane receptor.

Technology Process of (2S)-3-BroMo-N-[4-cyano-3-(trifluoroMethyl)phenyl]-2-hydroxy-2-Methyl-propanaMide

There total 4 articles about (2S)-3-BroMo-N-[4-cyano-3-(trifluoroMethyl)phenyl]-2-hydroxy-2-Methyl-propanaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 106089-20-7
(S)-(-)-3-bromo-2-hydroxy-2-methylpropanoic acid

: 113181-02-5
(S)-(-)-3-bromo-2-hydroxy-2-methyl-N-[(4-cyano-3-(trifluoromethyl)phenyl)]propanamide

Guidance literature:: With thionyl chloride; triethylamine;

Reference yield:

: 1010729-05-1
C₄H₆BrClO₂

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 113181-02-5
(S)-(-)-3-bromo-2-hydroxy-2-methyl-N-[(4-cyano-3-(trifluoromethyl)phenyl)]propanamide

Guidance literature:: In N,N-dimethyl acetamide; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.jorganchem.2010.10.051

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 927203-28-9
3-bromomethyl-3-methyl-tetrahydro-pyrrolo[2,1-c][1,4]oxazine-1,4-dione

: 113181-02-5
(S)-(-)-3-bromo-2-hydroxy-2-methyl-N-[(4-cyano-3-(trifluoromethyl)phenyl)]propanamide

: N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2S)-3-chloro-2-hydroxy-2-methylpropanamide

Guidance literature:: 3-bromomethyl-3-methyl-tetrahydro-pyrrolo[2,1-c][1,4]oxazine-1,4-dione; With hydrogenchloride; Heating;

With thionyl chloride; 2,4-dichlorophenoxyacetic acid dimethylamine; at -10 - -5 ℃;

4-amino-2-trifluoromethylbenzonitrile; With 2,4-dichlorophenoxyacetic acid dimethylamine; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/jm990027x