1-Piperidinecarboxylic acid, 4-cyano-4-[(2,3-dihydro-3-hydroxy-2-oxo-3-phenyl-1H-indol-1-yl)methyl]- , 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-cyano-4-[(2,3-dihydro-3-hydroxy-2-oxo-3-phenyl-1H-indol-1-yl)methyl]- , 1,1-dimethylethyl ester
CAS No.:113193-36-5
Molecular Formula:C26H29N3O4
Molecular Weight:447.534
Hs Code.:
Mol file:113193-36-5.mol

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 4-cyano-4-[(2,3-dihydro-3-hydroxy-2-oxo-3-phenyl-1H-indol-1-yl)methyl]- , 1,1-dimethylethyl ester

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Technology Process of 1-Piperidinecarboxylic acid, 4-cyano-4-[(2,3-dihydro-3-hydroxy-2-oxo-3-phenyl-1H-indol-1-yl)methyl]- , 1,1-dimethylethyl ester

There total 1 articles about 1-Piperidinecarboxylic acid, 4-cyano-4-[(2,3-dihydro-3-hydroxy-2-oxo-3-phenyl-1H-indol-1-yl)methyl]- , 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 139018-14-7,1848-24-4
3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one

: 117032-81-2
tert-butyl 4-(chloromethyl)-4-cyanopiperidine-1-carboxylate

: 113193-36-5
tert-butyl 4-<<1-<3-hydroxy-2(3H)-oxo-3-phenylindolyl>>methyl>-4-cyanopiperidine-1-carboxylate

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide; at 130 ℃; for 18h;
DOI:10.1021/jm00085a001

Reference yield:

: 113193-36-5
tert-butyl 4-<<1-<3-hydroxy-2(3H)-oxo-3-phenylindolyl>>methyl>-4-cyanopiperidine-1-carboxylate

: 112929-18-7
2',3',4',10'-tetrahydro-10'-hydroxy-10'-phenyl-1-(tert-butoxycarbonyl)spiroindole>

Guidance literature:: With ammonia; hydrogen; nickel; In ethanol; at 50 ℃; for 2h; under 3040 - 3800 Torr;
DOI:10.1021/jm00085a001

Reference yield:

: 113193-36-5
tert-butyl 4-<<1-<3-hydroxy-2(3H)-oxo-3-phenylindolyl>>methyl>-4-cyanopiperidine-1-carboxylate

: 139018-24-9
2',3',4',10'-tetrahydro-10'-hydroxy-10'-phenylspiroindole>

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, NH₃, Raney nickel / ethanol / 2 h / 50 °C / 3040 - 3800 Torr

2: HCl / ethanol / Heating

With hydrogenchloride; ammonia; hydrogen; nickel; In ethanol;
DOI:10.1021/jm00085a001