Salvianolic acid B

Base Information

• Chemical Name: Salvianolic acid B
• CAS No.: 115939-25-8
• Molecular Formula: C36H30O16
• Molecular Weight: 718.625
• Hs Code.: 29329990
• Mol file: 115939-25-8.mol

Synonyms:(2R-(2alpha,3beta(R*),4(E(R*))))-3-(1-Carboxy-2-(3,4-dihydroxyphenyl)ethyl) 4-(3-(1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy)-3-oxo-1-propenyl)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylate;2-[(2R,3R)-4-[(E)-2-[(1R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]carbonylethenyl]-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydrobenzofuran-3-carbonyl]oxy-3-(3,4-dihydroxyphenyl)propanoic acid;3-Benzofurancarboxylic acid,4-[(1E)-3-[(1R)-1-carboxy-2-(3,4- dihydroxyphenyl)ethoxy]-3-oxo-1-propenyl]- 2-(3,4-dihydroxyphenyl)-2,3-dihydro-7- hydroxy-,3-[(1R)-1-carboxy-2-(3,4- dihydroxyphenyl)ethyl] ester,(2R,3R)-;Lithospermate;3-Benzofurancarboxylic acid, 4-(3-(1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy)-3-oxo-1-propenyl)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-, 3-(1-carboxy-2-(3,4-dihydroxyphenyl)ethyl) ester, (2R-(2alpha,3beta(R*),4(E(R*))))-;

Chemical Property of Salvianolic acid B

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.739
• Boiling Point: 1020.3 °C at 760 mmHg
• Flash Point: 322.1 °C
• PSA: 278.04000
• Density: 1.637 g/cm³
• LogP: 3.33450
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)

Purity/Quality:

Tanshinone IIA 0.3%, ^*data from raw suppliers

Salvianolic acid B ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Salvianolic acid A (Sal A) and salvianolic acid B (Sal B) were isolated and purified from the crude extract of Salvia miltiorrhiza. Antioxidant activities of Sal A and Sal B were also evaluated and the ABTS results showed that Sal A and Sal B exhibited high total antioxidant activities, their EC50 values were 1.35 0.00 and 1.43 0.01 .mu.g/mL. This compound always contains a significant amount of residual solvent.

Technology Process of Salvianolic acid B

There total 2 articles about Salvianolic acid B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Magnesium lithospermate B → salvianolic acid B (55757-13-6,80996-17-4,115939-25-8,121521-90-2,135636-28-1)

Guidance literature:

With IR 120B resin (H⁽¹⁺⁾ form); Yield given;

DOI:10.1248/cpb.37.340

Reference yield:

ammonium-potassium lithospermate B (121570-16-9) → salvianolic acid B (55757-13-6,80996-17-4,115939-25-8,121521-90-2,135636-28-1)

Guidance literature:

With IR 120B resin (H⁽¹⁺⁾ form); Yield given;

DOI:10.1248/cpb.37.340

Reference yield: 66.0%

dimethyl sulfate (77-78-1) + salvianolic acid B (115939-25-8) → dimethyl heptamethyllithospermate B (121521-89-9)

Guidance literature:

With potassium carbonate; In acetone; for 5h; Heating;

DOI:10.1021/np060136w

upstream raw materials:

ammonium-potassium lithospermate B

Downstream raw materials:

ammonium-potassium lithospermate B

dipotassium salt of lithospermic acid B

calcium salt of lithospermic acid B

dimethyl heptamethyllithospermate B

Refernces