Nitrone, alpha-(m-hydroxyphenyl)-N-phenyl-

Base Information

• Chemical Name: Nitrone, alpha-(m-hydroxyphenyl)-N-phenyl-
• CAS No.: 19865-56-6
• Molecular Formula: C13H11NO2
• Molecular Weight: 213.236
• NSC Number: 102887
• Mol file: 19865-56-6.mol

Synonyms:Nitrone, .alpha.-(m-hydroxyphenyl)-N-phenyl-;Phenol, N-oxide;NSC102887;Phenol, 3-[(phenylimino)methyl]-, N-oxide;19865-56-6;NSC-102887;.alpha.-(3-Hydroxyphenyl)-N-phenyl nitrone

Chemical Property of Nitrone, alpha-(m-hydroxyphenyl)-N-phenyl-

Chemical Property:

• Vapor Pressure: 6.96E-08mmHg at 25°C
• Boiling Point: 426.7°Cat760mmHg
• Flash Point: 185.1°C
• Density: 1.245g/cm³
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 213.078978594
• Heavy Atom Count: 16
• Complexity: 246

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)[N+](=CC2=CC(=CC=C2)O)[O-]
• Isomeric SMILES: C1=CC=C(C=C1)/[N+](=C/C2=CC(=CC=C2)O)/[O-]

Technology Process of Nitrone, alpha-(m-hydroxyphenyl)-N-phenyl-

There total 3 articles about Nitrone, alpha-(m-hydroxyphenyl)-N-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

meta-hydroxybenzaldehyde (100-83-4) + N-Phenylhydroxylamine (100-65-2) → 3-hydroxy-benzaldehyde-(N-phenyl oxime ) (19865-56-6)

Guidance literature:

In glycerol; at 60 - 80 ℃; for 0.666667h; Green chemistry;

DOI:10.1007/s12039-019-1677-7

Reference yield:

nitrobenzene (98-95-3,26969-40-4) → 3-hydroxy-benzaldehyde-(N-phenyl oxime ) (19865-56-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride; zinc / water / 20 - 70 °C / Inert atmosphere

2: water / 20 °C / Inert atmosphere

With ammonium chloride; zinc; In water;

DOI:10.1016/j.ejmech.2011.11.037

Reference yield:

meta-hydroxybenzaldehyde (100-83-4) + N-Phenylhydroxylamine (100-65-2) → N-phenyl-α-(3-hydroxyphenyl)nitrone (19865-56-6)

Guidance literature:

In ethanol; Heating; sonication;

DOI:10.1021/ol701725r

upstream raw materials:

meta-hydroxybenzaldehyde

N-Phenylhydroxylamine

nitrobenzene

Downstream raw materials:

3-((phenylimino)methyl)phenol