Technology Process of 2,5-Piperazinedione,
1,4-bis(phenylmethyl)-3-[(2,4,5-trimethoxy-3-methylphenyl)methyl]-6-[(2,
4,5-trimethoxy-3-methylphenyl)methylene]-, (Z)-
There total 9 articles about 2,5-Piperazinedione,
1,4-bis(phenylmethyl)-3-[(2,4,5-trimethoxy-3-methylphenyl)methyl]-6-[(2,
4,5-trimethoxy-3-methylphenyl)methylene]-, (Z)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 66 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 24 h / Ambient temperature
2: 97 percent / H2 / 10percent palladium on carbon / ethanol; dimethylformamide / 4 h / 760 Torr
3: 83 percent / 4 h / 110 °C
4: 81 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 24 h / Ambient temperature
5: 89 percent / hydrazine hydrate / dimethylformamide / 12 h / Ambient temperature
6: 1.) sodium hydride / 1.) DMF, 0 deg C, 10 min, 2.) DMF, room temp., 2 h
7: 1.) sodium hydride / 1.) DMF, 0 deg C, 10 min, 2.) DMF, room temp., 30 min
With
potassium tert-butylate; hydrogen; sodium hydride; hydrazine hydrate;
palladium on activated charcoal;
In
ethanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.35.2525
- Guidance literature:
-
Multi-step reaction with 8 steps
2: 66 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 24 h / Ambient temperature
3: 97 percent / H2 / 10percent palladium on carbon / ethanol; dimethylformamide / 4 h / 760 Torr
4: 83 percent / 4 h / 110 °C
5: 81 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 24 h / Ambient temperature
6: 89 percent / hydrazine hydrate / dimethylformamide / 12 h / Ambient temperature
7: 1.) sodium hydride / 1.) DMF, 0 deg C, 10 min, 2.) DMF, room temp., 2 h
8: 1.) sodium hydride / 1.) DMF, 0 deg C, 10 min, 2.) DMF, room temp., 30 min
With
potassium tert-butylate; hydrogen; sodium hydride; hydrazine hydrate;
palladium on activated charcoal;
In
ethanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.35.2525
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 97 percent / H2 / 10percent palladium on carbon / ethanol; dimethylformamide / 4 h / 760 Torr
2: 83 percent / 4 h / 110 °C
3: 81 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 24 h / Ambient temperature
4: 89 percent / hydrazine hydrate / dimethylformamide / 12 h / Ambient temperature
5: 1.) sodium hydride / 1.) DMF, 0 deg C, 10 min, 2.) DMF, room temp., 2 h
6: 1.) sodium hydride / 1.) DMF, 0 deg C, 10 min, 2.) DMF, room temp., 30 min
With
potassium tert-butylate; hydrogen; sodium hydride; hydrazine hydrate;
palladium on activated charcoal;
In
ethanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.35.2525
