8-Benzyl-8-azabicyclo[3.2.1]oct-6-ene

Base Information

• Chemical Name: 8-Benzyl-8-azabicyclo[3.2.1]oct-6-ene
• CAS No.: 113340-17-3
• Molecular Formula: C₁₄H₁₇N
• Molecular Weight: 199.296
• DSSTox Substance ID: DTXSID20572799
• Mol file: 113340-17-3.mol

Synonyms:8-Benzyl-8-azabicyclo[3.2.1]oct-6-ene;113340-17-3;DTXSID20572799

Chemical Property of 8-Benzyl-8-azabicyclo[3.2.1]oct-6-ene

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 199.136099547
• Heavy Atom Count: 15
• Complexity: 226

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2C=CC(C1)N2CC3=CC=CC=C3

Technology Process of 8-Benzyl-8-azabicyclo[3.2.1]oct-6-ene

There total 8 articles about 8-Benzyl-8-azabicyclo[3.2.1]oct-6-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzyl-((1R,4S)-4-bromo-cyclohept-2-enyl)-amine; hydrobromide → 8-Benzyl-8-aza-bicyclo[5.1.0]oct-2-ene (113340-12-8) + 8-benzyl-8-azabicyclo(3.2.1)oct-6-ene (113340-17-3)

Guidance literature:

With tetramethylpyridine; In acetone; at 50 ℃; for 19h; Yield given. Yields of byproduct given; sonicated;

DOI:10.1016/S0040-4020(01)80313-6

Reference yield:

Benzyl-((1R,4S)-4-chloro-cyclohept-2-enyl)-amine; hydrochloride → 8-Benzyl-8-aza-bicyclo[5.1.0]oct-2-ene (113340-12-8) + 8-benzyl-8-azabicyclo(3.2.1)oct-6-ene (113340-17-3)

Guidance literature:

With potassium carbonate; In chloroform; at 0 ℃; for 24h; Yield given. Yields of byproduct given; sonicated;

DOI:10.1016/S0040-4020(01)80313-6

Reference yield:

cis-4-(benzoylamino)-2-cycloheptenol (95687-90-4) → 8-benzyl-8-azabicyclo(3.2.1)oct-6-ene (113340-17-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / LiAlH₄ / diethyl ether / Heating

2: SOBr₂ / CDCl₃ / 4 h / 0 °C

3: tetramethylpyridine / acetone / 19 h / 50 °C

With lithium aluminium tetrahydride; sulfurous dibromide; tetramethylpyridine; In diethyl ether; chloroform-d1; acetone;

DOI:10.1016/S0040-4020(01)80313-6

upstream raw materials:

Benzyl-((1R,4R)-4-chloro-cyclohept-2-enyl)-amine; hydrochloride

4-(N-benzylamino)cyclohept-2-en-1-ol

cis-4-(benzoylamino)-2-cycloheptenol

N-benzoyl-8-oxa-9-azabicyclo<3.2.2>non-6-ene