Chemical Property of Atizoram
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Refractive Index:1.56
- Boiling Point:543.028 °C at 760 mmHg
- PKA:14.05±0.40(Predicted)
- Flash Point:282.213 °C
- PSA：59.59000
- Density:1.178 g/cm3
- LogP:3.31660
- Storage Temp.:Store at +4°C
- XLogP3:2.6
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:4
- Exact Mass:316.17869263
- Heavy Atom Count:23
- Complexity:434
- Purity/Quality:
-
99% *data from raw suppliers
CP 80633 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:COC1=C(C=C(C=C1)C2CNC(=O)NC2)OC3CC4CCC3C4
- Isomeric SMILES:COC1=C(C=C(C=C1)C2CNC(=O)NC2)O[C@H]3C[C@@H]4CC[C@H]3C4
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Uses
Phosphodiesterases (PDE) enzymatically convert the cyclic nucleotide second messengers cAMP and cGMP to 5’-AMP and 5’-GMP, respectively, thus terminating signal transduction. The cAMP-specific PDE4 isoforms may be particularly important in certain respiratory and neurological diseases. CP 80,633 is a selective inhibitor of PDE4 (IC50 = 1.27 μM for PDE4 versus. >100 μM for PDE1, PDE2, PDE3, and PDE5). It potentiates PGE1-dependent increases in cAMP levels in eosinophils, monocytes, and T-cells, inhibits eosinophil superoxide production (IC50 < 0.6 μM), and blocks LPS-induced TNF-α release from monocytes (IC50 = 0.22 μM). CP 80,633 (1 mg/kg) significantly reduces antigen-induced airway inflammation in atopic guinea pigs, monkeys, and mice.[Cayman Chemical] CP 80633 is a selective inhibitor of phosphodiesterase type 4.
