2-Hydroxy-3-iodo-6-methoxybenzoic acid

Base Information

Chemical Name:2-Hydroxy-3-iodo-6-methoxybenzoic acid
CAS No.:113452-76-9
Molecular Formula:C8H7IO4
Molecular Weight:294.04300
Hs Code.:
DSSTox Substance ID:DTXSID60555263
Wikidata:Q82436564
Mol file:113452-76-9.mol

Synonyms:2-hydroxy-3-iodo-6-methoxybenzoic acid;113452-76-9;DTXSID60555263

Suppliers and Price of 2-Hydroxy-3-iodo-6-methoxybenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Hydroxy-3-iodo-6-methoxybenzoic acid

Chemical Property:

Boiling Point:333.9±42.0 °C(Predicted)
PKA:2.47±0.25(Predicted)
PSA：66.76000
Density:2.007±0.06 g/cm3(Predicted)
LogP:1.70360
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:293.93891
Heavy Atom Count:13
Complexity:197

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C(=C(C=C1)I)O)C(=O)O

Technology Process of 2-Hydroxy-3-iodo-6-methoxybenzoic acid

There total 2 articles about 2-Hydroxy-3-iodo-6-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 3147-64-6
2-hydroxy-6-methoxybenzoic acid

: 113452-76-9
3-iodo-6-methoxysalicylic acid

Guidance literature:: With Iodine monochloride; In acetic acid; 1.) reflux, 3 h, 2.) room temperature, 18 h;
DOI:10.1021/jm00400a027

Reference yield:

: 1466-76-8
2-6-dimethoxybenzoic acid

: 113452-76-9
3-iodo-6-methoxysalicylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / HBr, AcOH / CHCl₃ / 20 h / Ambient temperature

2: 70 percent / ICl / acetic acid / 1.) reflux, 3 h, 2.) room temperature, 18 h

With hydrogen bromide; Iodine monochloride; acetic acid; In chloroform; acetic acid;
DOI:10.1021/jm00400a027