2-Amino-3-methyl-5-phenylpyridine

Base Information

• Chemical Name: 2-Amino-3-methyl-5-phenylpyridine
• CAS No.: 114042-03-4
• Molecular Formula: C12H12 N2
• Molecular Weight: 184.241
• DSSTox Substance ID: DTXSID80150638
• Nikkaji Number: J239.121J
• Wikidata: Q83016793
• Mol file: 114042-03-4.mol

Synonyms:2-amino-3-methyl-5-phenylpyridine;MeAPP

Chemical Property of 2-Amino-3-methyl-5-phenylpyridine

Chemical Property:

• Vapor Pressure: 0.000203mmHg at 25°C
• Boiling Point: 327.4°Cat760mmHg
• PKA: 6.62±0.49(Predicted)
• Flash Point: 178°C
• PSA: 39.64000
• Density: 1.106g/cm³
• LogP: 2.56930
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 184.100048391
• Heavy Atom Count: 14
• Complexity: 175

Purity/Quality:

99%min ^*data from raw suppliers

2-AMINO-3-METHYL-5-PHENYLPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CN=C1N)C2=CC=CC=C2

Technology Process of 2-Amino-3-methyl-5-phenylpyridine

There total 2 articles about 2-Amino-3-methyl-5-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-bromo-3-methyl-pyridin-2-ylamine (3430-21-5) + phenylboronic acid (98-80-6) → 3-methyl-5-phenylpyridin-2-amine (114042-03-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; for 3h; Heating;

DOI:10.3987/R-1987-10-2711

Reference yield:

→ 3-methyl-5-phenylpyridin-2-amine (114042-03-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; for 18h; Reflux;

Reference yield: 56.1%

4-(1,3-dioxo-3a,4,7,7a-tetrahydro-1H-isoindol-2(3H)-yl)butanoic acid (13053-43-5) + 3-methyl-5-phenylpyridin-2-amine (114042-03-4) → C24H25N3O3

Guidance literature:

4-(1,3-dioxo-3a,4,7,7a-tetrahydro-1H-isoindol-2(3H)-yl)butanoic acid; With triethylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate; In dichloromethane; at 20 ℃; for 0.166667h;

3-methyl-5-phenylpyridin-2-amine; In dichloromethane; at 20 ℃; for 24h;

upstream raw materials:

5-bromo-3-methyl-pyridin-2-ylamine

phenylboronic acid

Refernces

• 1、 Stavenuiter, Johannes,Hamzink, Martin,Hulst, Rob van der,Zomer, Gijsbert,Westra, Gerard,Kriek, Erik. "PALLADIUM-CATALYZED CROSS-COUPLING OF PHENYLBORONIC ACID WITH HETEROCYCLIC AROMATIC HALIDES". . p. 2711 - 2716. Retrieved 2007/10/02.