Technology Process of Propanedioic acid,
[[1-[(4-methoxyphenyl)diphenylmethyl]-4-methyl-2,5-dioxo-4-(2-propenyl
)-3-pyrrolidinylidene]methyl]-, 1,1-dimethylethyl methyl ester
There total 32 articles about Propanedioic acid,
[[1-[(4-methoxyphenyl)diphenylmethyl]-4-methyl-2,5-dioxo-4-(2-propenyl
)-3-pyrrolidinylidene]methyl]-, 1,1-dimethylethyl methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
3: 420 mg / ammonia / tetrahydrofuran; H2O / -75 °C
4: 80 percent / sodium ethoxyde / ethanol / 1.5 h / 20 °C
5: 250 mg / 0.3M hydrochloric acid / H2O / 3 h / Heating
6: 1.) potassium t-butoxide / 1.) THF, t-butyl alcohol, DMF, 0 deg C, 10 min, 2.) THF, t-butyl alcohol, DMF, 0 deg C, 2 h
8: 1.) sodium hydride / 1.) THF, 0 deg C, 30 min, 2.) THF, 18 deg C, 1 h
9: tetrahydrofuran; hexamethylphosphoric acid triamide / 16 h / 18 °C
With
hydrogenchloride; potassium tert-butylate; ammonia; sodium ethanolate; sodium hydride;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; water;
- Guidance literature:
-
Multi-step reaction with 9 steps
3: 420 mg / ammonia / tetrahydrofuran; H2O / -75 °C
4: 80 percent / sodium ethoxyde / ethanol / 1.5 h / 20 °C
5: 250 mg / 0.3M hydrochloric acid / H2O / 3 h / Heating
6: 1.) potassium t-butoxide / 1.) THF, t-butyl alcohol, DMF, 0 deg C, 10 min, 2.) THF, t-butyl alcohol, DMF, 0 deg C, 2 h
8: 1.) sodium hydride / 1.) THF, 0 deg C, 30 min, 2.) THF, 18 deg C, 1 h
9: tetrahydrofuran; hexamethylphosphoric acid triamide / 16 h / 18 °C
With
hydrogenchloride; potassium tert-butylate; ammonia; sodium ethanolate; sodium hydride;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
2: 420 mg / ammonia / tetrahydrofuran; H2O / -75 °C
3: 80 percent / sodium ethoxyde / ethanol / 1.5 h / 20 °C
4: 250 mg / 0.3M hydrochloric acid / H2O / 3 h / Heating
5: 1.) potassium t-butoxide / 1.) THF, t-butyl alcohol, DMF, 0 deg C, 10 min, 2.) THF, t-butyl alcohol, DMF, 0 deg C, 2 h
7: 1.) sodium hydride / 1.) THF, 0 deg C, 30 min, 2.) THF, 18 deg C, 1 h
8: tetrahydrofuran; hexamethylphosphoric acid triamide / 16 h / 18 °C
With
hydrogenchloride; potassium tert-butylate; ammonia; sodium ethanolate; sodium hydride;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; water;
