Lombazole

Base Information

• Chemical Name: Lombazole
• CAS No.: 60628-98-0
• Molecular Formula: C22H17 Cl N2
• Molecular Weight: 344.843
• Hs Code.: 2933290090
• European Community (EC) Number: 262-337-1
• UNII: ZHC772U9S3
• DSSTox Substance ID: DTXSID00976059
• Nikkaji Number: J18.952I
• Wikidata: Q27295514
• NCI Thesaurus Code: C81512
• ChEMBL ID: CHEMBL2105144
• Mol file: 60628-98-0.mol

Synonyms:4-biphenylyl-(2-chlorophenyl)-1-imidazolylmethane;Bay h 6020;Bay h-6020;lombazole

Chemical Property of Lombazole

Chemical Property:

• Vapor Pressure: 4.06E-10mmHg at 25°C
• Boiling Point: 512.7°C at 760 mmHg
• PKA: 6.33±0.24(Predicted)
• Flash Point: 263.9°C
• PSA: 17.82000
• Density: 1.15g/cm³
• LogP: 5.84120
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 344.1080262
• Heavy Atom Count: 25
• Complexity: 401

Purity/Quality:

98%Min ^*data from raw suppliers

Lombazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)C(C3=CC=CC=C3Cl)N4C=CN=C4
• Uses: Lombazole is imidazole based antimicrobial agent. Also reported to have some antifungal activity.

Technology Process of Lombazole

There total 3 articles about Lombazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1H-imidazole (288-32-4) + α-(biphenyl-4-yl)-2-chlorobenzyl chloride (60629-26-7) → 1-[biphenyl-4-yl-(2-chloro-phenyl)-methyl]-1H-imidazole (60628-98-0)

Guidance literature:

With sodium methylate; In chloroform; ethyl acetate; acetonitrile;

Reference yield:

→ (biphenyl-4-yl)-imidazol-1-yl-(4-chlorophenyl)methane + 1-[biphenyl-4-yl-(2-chloro-phenyl)-methyl]-1H-imidazole (60628-98-0)

Guidance literature:

Reference yield:

→ 1-[biphenyl-4-yl-(2-chloro-phenyl)-methyl]-1H-imidazole (60628-98-0)

Guidance literature:

Imidazol, NaOMe, 2-Chlor-phenyl-diphenylchlormethan;

upstream raw materials:

1H-imidazole

α-(biphenyl-4-yl)-2-chlorobenzyl chloride

Refernces