Phenol, 4-[2-(3-chloro-2-quinoxalinyl)ethenyl]-, acetate (ester)

Base Information

• Chemical Name: Phenol, 4-[2-(3-chloro-2-quinoxalinyl)ethenyl]-, acetate (ester)
• CAS No.: 113711-53-8
• Molecular Formula: C₁₈H₁₃ClN₂O₂
• Molecular Weight: 324.766
• Mol file: 113711-53-8.mol

Synonyms:Acetic acid 4-[(E)-2-(3-chloro-quinoxalin-2-yl)-vinyl]-phenyl ester;

Chemical Property of Phenol, 4-[2-(3-chloro-2-quinoxalinyl)ethenyl]-, acetate (ester)

Chemical Property:

• PSA: 52.08000
• LogP: 4.37890

Purity/Quality:

[4-[(E)-2-(3-CHLOROQUINOXALIN-2-YL)ETHENYL]PHENYL] ACETATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 4-[2-(3-chloro-2-quinoxalinyl)ethenyl]-, acetate (ester)

There total 3 articles about Phenol, 4-[2-(3-chloro-2-quinoxalinyl)ethenyl]-, acetate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.8%

2-(p-Acetoxystyryl)-3-hydroxyquinoxaline (113711-50-5) → 2-(p-Acetoxystyryl)-3-chloroquinoxaline (113711-53-8)

Guidance literature:

With pyridine; trichlorophosphate; for 0.666667h; Heating;

DOI:10.1007/BF00757962

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 2-(p-Acetoxystyryl)-3-chloroquinoxaline (113711-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 48.9 percent / CH₃COONa / 9 h / 148 - 152 °C

2: 75.8 percent / POCl₃, pyridine / 0.67 h / Heating

With pyridine; sodium acetate; trichlorophosphate;

DOI:10.1007/BF00757962

Reference yield:

3-methylquinoxalin-2-ol (14003-34-0) → 2-(p-Acetoxystyryl)-3-chloroquinoxaline (113711-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 48.9 percent / CH₃COONa / 9 h / 148 - 152 °C

2: 75.8 percent / POCl₃, pyridine / 0.67 h / Heating

With pyridine; sodium acetate; trichlorophosphate;

DOI:10.1007/BF00757962

upstream raw materials:

2-(p-Acetoxystyryl)-3-hydroxyquinoxaline

4-hydroxy-benzaldehyde

3-methylquinoxalin-2-ol