2-Benzofurancarboxylic acid, 4-benzoyl-6,7-dichloro-2,3-dihydro-

Base Information

Chemical Name:2-Benzofurancarboxylic acid, 4-benzoyl-6,7-dichloro-2,3-dihydro-
CAS No.:113730-47-5
Molecular Formula:C16H10Cl2O4
Molecular Weight:337.159
Hs Code.:
Mol file:113730-47-5.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Benzofurancarboxylic acid, 4-benzoyl-6,7-dichloro-2,3-dihydro-

Chemical Property:

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Technology Process of 2-Benzofurancarboxylic acid, 4-benzoyl-6,7-dichloro-2,3-dihydro-

There total 10 articles about 2-Benzofurancarboxylic acid, 4-benzoyl-6,7-dichloro-2,3-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 113730-44-2
6,7-dichloro-2-hydroxymethyl-2,3-dihydrobenzofuran-4-yl phenyl ketone

: 113730-47-5
4-benzoyl-6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid

Guidance literature:: With jones reagent; In acetone; at 15 ℃; for 7.5h;
DOI:10.1248/cpb.35.3215

Reference yield:

: 576-24-9
2,3-dichlorophenol

: 113730-47-5
4-benzoyl-6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 42 percent / HNO₃ / acetic anhydride; acetic acid / 1 h / 4 - 8 °C

2: 97 percent / potassium carbonate / dimethylformamide / 0.67 h / Heating

3: H₂ / Pd-C (10percent) / ethyl acetate

4: 1.) BCl₃, AlCl₃; 2.) HCl (20percent) / 1.) CH₂Cl₂, room temp., 30 min; reflux, 2 h; 2.) 70 deg C, 10 min

5: 1.) NOSO₄H (45percent); 2.) H₃PO₂ / 1.) H₂SO₄, THF, -25 to 0 deg C, 1.5 h; 2.) 6-10 deg C, 2 h

6: 98 percent / BBr₃ / CH₂Cl₂ / 1.) 5 deg C, 1 h; 2.) room temp., 20 min

7: 97 percent / potassium carbonate / dimethylformamide / Ambient temperature

8: 67 percent / 0.13 h / 235 °C

9: 76 percent / m-CPBA, KF / CH₂Cl₂ / 17 h

10: 54 percent / Jones reagent / acetone / 7.5 h / 15 °C

With hydrogenchloride; potassium fluoride; aluminium trichloride; jones reagent; nitrosylsulfuric acid; hydrogen; nitric acid; hypophosphorous acid; boron trichloride; boron tribromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In dichloromethane; acetic anhydride; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.35.3215

Reference yield:

: 105630-54-4
2,3-dichloro-1-methoxy-4-nitrobenzene

: 113730-47-5
4-benzoyl-6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / Pd-C (10percent) / ethyl acetate

2: 1.) BCl₃, AlCl₃; 2.) HCl (20percent) / 1.) CH₂Cl₂, room temp., 30 min; reflux, 2 h; 2.) 70 deg C, 10 min

3: 1.) NOSO₄H (45percent); 2.) H₃PO₂ / 1.) H₂SO₄, THF, -25 to 0 deg C, 1.5 h; 2.) 6-10 deg C, 2 h

4: 98 percent / BBr₃ / CH₂Cl₂ / 1.) 5 deg C, 1 h; 2.) room temp., 20 min

5: 97 percent / potassium carbonate / dimethylformamide / Ambient temperature

6: 67 percent / 0.13 h / 235 °C

7: 76 percent / m-CPBA, KF / CH₂Cl₂ / 17 h

8: 54 percent / Jones reagent / acetone / 7.5 h / 15 °C

With hydrogenchloride; potassium fluoride; aluminium trichloride; jones reagent; nitrosylsulfuric acid; hydrogen; hypophosphorous acid; boron trichloride; boron tribromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.35.3215