L-Leucine, N-[3-(6-amino-9H-purin-9-yl)-N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]- L-tyrosyl]-D-alanyl]glycyl]-L-alanyl]-, methyl ester

Base Information

Chemical Name:L-Leucine, N-[3-(6-amino-9H-purin-9-yl)-N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]- L-tyrosyl]-D-alanyl]glycyl]-L-alanyl]-, methyl ester
CAS No.:113845-43-5
Molecular Formula:C₃₄H₄₈N₁₀O₉
Molecular Weight:740.817
Hs Code.:
Mol file:113845-43-5.mol

Synonyms:

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Chemical Property of L-Leucine, N-[3-(6-amino-9H-purin-9-yl)-N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]- L-tyrosyl]-D-alanyl]glycyl]-L-alanyl]-, methyl ester

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Technology Process of L-Leucine, N-[3-(6-amino-9H-purin-9-yl)-N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]- L-tyrosyl]-D-alanyl]glycyl]-L-alanyl]-, methyl ester

There total 4 articles about L-Leucine, N-[3-(6-amino-9H-purin-9-yl)-N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]- L-tyrosyl]-D-alanyl]glycyl]-L-alanyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 64410-47-5,79225-08-4
N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine

: L-β-(adeninyl-N⁹)-α-alanyl-L-leucine methyl ester trifluoroacetate

: 113845-43-5
N-Boc-L-tyrosyl-D-alanyl-glycl-L-β-(adeninyl-N⁹)-α-alanyl-L-leucine methyl ester

Guidance literature:: With 2,3,4,5,6-pentafluorophenol; triethylamine; dicyclohexyl-carbodiimide;

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 113845-43-5
N-Boc-L-tyrosyl-D-alanyl-glycl-L-β-(adeninyl-N⁹)-α-alanyl-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methylmorpholine, DCC, 1-hydroxybenzotriazole / 1.) 1 h, 0 deg C, 7 h, 20 deg C

2: 1 N aq. NaOH / methanol; dioxane / 0.33 h / 20 °C

3: 36 percent / 4-methylmorpholine, DCC, 1-hydroxybenzotriazole

4: 80 percent / 1 N aq. NaOH / methanol; dioxane / 0.42 h / 20 °C

5: 52 percent / triethylamine, pentafluorophenol, DCC

With 4-methyl-morpholine; sodium hydroxide; 2,3,4,5,6-pentafluorophenol; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol;

Reference yield:

: 71591-34-9
N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanine

: 113845-43-5
N-Boc-L-tyrosyl-D-alanyl-glycl-L-β-(adeninyl-N⁹)-α-alanyl-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 36 percent / 4-methylmorpholine, DCC, 1-hydroxybenzotriazole

2: 80 percent / 1 N aq. NaOH / methanol; dioxane / 0.42 h / 20 °C

3: 52 percent / triethylamine, pentafluorophenol, DCC

With 4-methyl-morpholine; sodium hydroxide; 2,3,4,5,6-pentafluorophenol; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol;