Methyl 5-diethoxyphosphoryl-2-hydroxy-4-oxopentanoate

Base Information

Chemical Name:Methyl 5-diethoxyphosphoryl-2-hydroxy-4-oxopentanoate
CAS No.:113848-01-4
Molecular Formula:C10H19O7P
Molecular Weight:282.22700
Hs Code.:
DSSTox Substance ID:DTXSID301347939
Nikkaji Number:J354.907K
Mol file:113848-01-4.mol

Synonyms:113848-01-4;methyl 5-diethoxyphosphoryl-2-hydroxy-4-oxopentanoate;5-Diethoxyphosphinyl-2-hydroxy-4-oxopentanoic acid methyl ester;DTXSID301347939;Methyl 5-(diethoxyphosphoryl)-2-hydroxy-4-oxopentanoate;1-DIETHOXYPHOSPHORYL-4-HYDROXY-4-METHOXYCARBONYLBUTAN-2-ONE

Suppliers and Price of Methyl 5-diethoxyphosphoryl-2-hydroxy-4-oxopentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Methyl 5-diethoxyphosphoryl-2-hydroxy-4-oxopentanoate

Chemical Property:

PSA：108.94000
LogP:0.74560
XLogP3:-0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:10
Exact Mass:282.08683994
Heavy Atom Count:18
Complexity:318

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOP(=O)(CC(=O)CC(C(=O)OC)O)OCC

Technology Process of Methyl 5-diethoxyphosphoryl-2-hydroxy-4-oxopentanoate

There total 3 articles about Methyl 5-diethoxyphosphoryl-2-hydroxy-4-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 107487-02-5
3-(Diethoxy-phosphorylmethyl)-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester

: 113848-01-4
methyl 5-(diethoxyphosphinyl)-2-hydroxy-4-oxopentanoate

Guidance literature:: With hydrogen; boric acid; Raney Ni (W-2); In ethanol; water; for 13h; under 760 Torr; Ambient temperature;
DOI:10.1246/bcsj.60.2463

Reference yield:

: 1606-75-3
(2-oxoethyl)phosphonic acid diethyl ester

: 113848-01-4
methyl 5-(diethoxyphosphinyl)-2-hydroxy-4-oxopentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / aq. hydroxylamine hydrochloride / ethanol / 11.5 h / Ambient temperature

2: 1.) NBS; 2.) triethylamine / 1.) DMF, -20 deg C, 1 h, 0 deg C, 30 min; 2.) DMF, Et₂O, RT, 18 h

3: 63 percent / boric acid, H₂ / Raney Ni (W-2) / ethanol; H₂O / 13 h / 760 Torr / Ambient temperature

With N-Bromosuccinimide; hydroxylamine hydrochloride; hydrogen; boric acid; triethylamine; Raney Ni (W-2); In ethanol; water;
DOI:10.1246/bcsj.60.2463

Reference yield:

: 110841-50-4
N-<2-(diethoxyphosphoryl)ethylidene>hydroxylamine

: 113848-01-4
methyl 5-(diethoxyphosphinyl)-2-hydroxy-4-oxopentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NBS; 2.) triethylamine / 1.) DMF, -20 deg C, 1 h, 0 deg C, 30 min; 2.) DMF, Et₂O, RT, 18 h

2: 63 percent / boric acid, H₂ / Raney Ni (W-2) / ethanol; H₂O / 13 h / 760 Torr / Ambient temperature

With N-Bromosuccinimide; hydrogen; boric acid; triethylamine; Raney Ni (W-2); In ethanol; water;
DOI:10.1246/bcsj.60.2463