Wiskostatin

Base Information

• Chemical Name: Wiskostatin
• CAS No.: 253449-04-6
• Molecular Formula: C17H18Br2N2O
• Molecular Weight: 426.1456
• Hs Code.: 2933990090
• European Community (EC) Number: 686-020-6
• DSSTox Substance ID: DTXSID80893518
• Nikkaji Number: J2.300.526C
• Wikidata: Q27147585
• Metabolomics Workbench ID: 144268
• ChEMBL ID: CHEMBL1476463
• Mol file: 253449-04-6.mol

Synonyms:wiskostatin

Chemical Property of Wiskostatin

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 0.000134mmHg at 25°C
• Melting Point: 153-155 °C
• Refractive Index: 1.657
• Boiling Point: 320.2 °C at 760 mmHg
• PKA: 14.40±0.20(Predicted)
• Flash Point: 147.4 °C
• PSA: 28.40000
• Density: 1.62 g/cm³
• LogP: 4.24200
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble10mg/mL, clear
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 425.97654
• Heavy Atom Count: 22
• Complexity: 356

Purity/Quality:

97% ^*data from raw suppliers

Wiskostatin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C)CC(CN1C2=C(C=C(C=C2)Br)C3=C1C=CC(=C3)Br)O
• Description: Wiskostatin (253449-04-6) is a selective, reversible inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity1. Binds to the regulatory domain of N-WASP and inhibits activation of Arp2/3 complex by forcing N-WASP into an inactive conformation2. Inhibits PIP2-induced actin polymerization (EC50=4 μM). Wiskostatin perturbs agrin-elicited acetylcholine receptor clustering3. Inhibits the formation of dendritic spines and synapses in hippocampal neurons.
• Uses: Wiskostatin has been used:as a small-molecule inhibitor of Wiskott-Aldrich syndrome protein (WASP) in human osteosarcoma U2OS cells and mouse-tail fibroblast cell lines as a neural (N)-WASP inhibitor in cultured neurons and in the human embryonic kidney (HEK293) cells expressing HA-Parkinas a neural (N)-WASP inhibitor in dorsal root ganglion (DRG) cells to investigate vascular endothelial growth factor (VEGF) effect on the actin related protein 2/3 complex (Arp 2/3)