9-methoxy-1,5-dimethyl-6H-pyrido[4,3-b]carbazole

Base Information

• Chemical Name: 9-methoxy-1,5-dimethyl-6H-pyrido[4,3-b]carbazole
• CAS No.: 16101-08-9
• Molecular Formula: C18H16 N2 O
• Molecular Weight: 276.338
• Hs Code.: 2933990090
• Mol file: 16101-08-9.mol

Synonyms:10-Methoxyolivacine;9-Methoxyolivacine

Chemical Property of 9-methoxy-1,5-dimethyl-6H-pyrido[4,3-b]carbazole

Chemical Property:

• Vapor Pressure: 1.59E-10mmHg at 25°C
• Melting Point: 291-293 °C
• Boiling Point: 523.4°Cat760mmHg
• PKA: 16.23±0.40(Predicted)
• Flash Point: 168.1°C
• PSA: 37.91000
• Density: 1.256g/cm³
• LogP: 4.49470

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-methoxy-1,5-dimethyl-6H-pyrido[4,3-b]carbazole

There total 19 articles about 9-methoxy-1,5-dimethyl-6H-pyrido[4,3-b]carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

dimethyl-1,5 dihydro-3,4 methoxy-9-6H-pyrido<4,3-b>carbazole (95835-26-0) → 9-methoxyellipticine (16101-08-9)

Guidance literature:

With palladium on activated charcoal; In decalin; for 2h; Heating;

Reference yield: 62.0%

N-(2-chloro-4-methoxyphenyl)-1,5-dimethylisoquinolin-6-amine → 10-methoxy-4,11b-dimethyl-11bH-pyrido[3,4-c]carbazole + 9-methoxyellipticine (16101-08-9)

Guidance literature:

With palladium diacetate; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In N,N-dimethyl-formamide; at 140 ℃; for 0.583333h; Inert atmosphere;

DOI:10.3390/molecules23061402

Reference yield: 40.0%

9-methoxyguatambuine (95589-87-0,16101-11-4) → 9-methoxyellipticine (16101-08-9)

Guidance literature:

palladium on activated charcoal; In decalin; for 24h; Heating;

DOI:10.1021/jm00383a004

upstream raw materials:

dimethyl-1,5 dihydro-3,4 methoxy-9-6H-pyrido<4,3-b>carbazole

9-methoxyguatambuine

2-<2-(acetylmethylamino)ethyl>-6-methoxy-1-methyl-9H-carbazole

4,6-dihydro-9-methoxy-1,2,5-trimethyl-3H-pyrido[4,3-b]carbazolium chloride

Downstream raw materials:

9-hydroxyolivacine

Refernces

• 1、 Maftouh,Besselievre,Monsarrat,Lesca,Meunier,Husson,Paoletti. "Synthesis and cytotoxic activity of hydroxylated derivatives of olivacine in relation with their biotransformation". . p. 708 - 714. Retrieved 2007/10/02.