6-Methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-acetic acid ethyl ester

Base Information

• Chemical Name: 6-Methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-acetic acid ethyl ester
• CAS No.: 54804-24-9
• Molecular Formula: C₁₃H₁₈N₂O₃
• Molecular Weight: 250.298
• Mol file: 54804-24-9.mol

Synonyms:(6-Methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl)-acetic acid ethyl ester;

Chemical Property of 6-Methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-acetic acid ethyl ester

Chemical Property:

• PSA: 61.19000
• LogP: 1.24620

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-acetic acid ethyl ester

There total 1 articles about 6-Methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-(ethoxycarbonylmethyl)-6-methyl-4-oxopyrido<1,2-a>pyrimidine (50609-57-9) → (6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl)-acetic acid ethyl ester (54804-24-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr;

DOI:10.1021/jo00353a024

Reference yield: 51.0%

N-methyl-N-phenylformamide (93-61-8) + (6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl)-acetic acid ethyl ester (54804-24-9) → {6-Methyl-9-[1-(methyl-phenyl-amino)-meth-(E)-ylidene]-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl}-acetic acid ethyl ester (101478-30-2)

Guidance literature:

With trichlorophosphate; In 1,2-dichloro-ethane; for 1h; Heating;

DOI:10.1002/jhet.5570220302

upstream raw materials:

3-(ethoxycarbonylmethyl)-6-methyl-4-oxopyrido<1,2-a>pyrimidine

Downstream raw materials:

{6-Methyl-9-[1-(methyl-phenyl-amino)-meth-(E)-ylidene]-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl}-acetic acid ethyl ester