2,2-DiMethyl-3-(2-Methyl-1-propenyl)cyclopropanecarbohydrazide

Base Information

• Chemical Name: 2,2-DiMethyl-3-(2-Methyl-1-propenyl)cyclopropanecarbohydrazide
• CAS No.: 113904-76-0
• Molecular Formula: C10H18N2O
• Molecular Weight: 182.26300
• Mol file: 113904-76-0.mol

Synonyms:Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propen-1-yl)-, hydrazide;2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarbohydrazide;Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, hydrazide (9CI);2,2-Dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carbohydrazide;

Chemical Property of 2,2-DiMethyl-3-(2-Methyl-1-propenyl)cyclopropanecarbohydrazide

Chemical Property:

• Boiling Point: 307.7±22.0 °C(Predicted)
• PKA: 13.44±0.60(Predicted)
• PSA: 55.12000
• Density: 1.065±0.06 g/cm3(Predicted)
• LogP: 2.30590
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-DiMethyl-3-(2-Methyl-1-propenyl)cyclopropanecarbohydrazide

There total 1 articles about 2,2-DiMethyl-3-(2-Methyl-1-propenyl)cyclopropanecarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.2%

ethyl 2,2-dimethyl-3-(2-methylpropenyl)-cyclopropanecarboxylate (41641-25-2) → (1R,3R)?2,2?dimethyl?3?(2?methylprop?1?en?1?yl)cyclopropane?1?carbohydrazide (113904-76-0)

Guidance literature:

With hydrazine hydrate; In ethanol; at 100 ℃; for 18h; Reflux;

DOI:10.1007/s11696-019-01012-4

Reference yield:

(1R,3R)?2,2?dimethyl?3?(2?methylprop?1?en?1?yl)cyclopropane?1?carbohydrazide (113904-76-0) → (E)-2-((5-(2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropyl)-1,3,4-oxadiazol-2-yl)thio)-N'-(2-(trifluoromethyl)benzylidene)acetohydrazide

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 18 h / 20 - 72 °C

1.2: pH 4 - 5

2.1: potassium carbonate; potassium iodide / ethanol / 20 - 72 °C

3.1: hydrazine hydrate / 10 h / 20 - 100 °C

4.1: ethanol / 90 °C / Sealed tube; Microwave irradiation

With potassium carbonate; hydrazine hydrate; potassium iodide; potassium hydroxide; In ethanol;

DOI:10.1080/10426507.2019.1700416

Reference yield:

(1R,3R)?2,2?dimethyl?3?(2?methylprop?1?en?1?yl)cyclopropane?1?carbohydrazide (113904-76-0) → (E)-2-((5-(2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropyl)-1,3,4-oxadiazol-2-yl)thio)-N'-(4-(trifluoromethyl)benzylidene)acetohydrazide

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 18 h / 20 - 72 °C

1.2: pH 4 - 5

2.1: potassium carbonate; potassium iodide / ethanol / 20 - 72 °C

3.1: hydrazine hydrate / 10 h / 20 - 100 °C

4.1: ethanol / 90 °C / Sealed tube; Microwave irradiation

With potassium carbonate; hydrazine hydrate; potassium iodide; potassium hydroxide; In ethanol;

DOI:10.1080/10426507.2019.1700416

upstream raw materials:

ethyl 2,2-dimethyl-3-(2-methylpropenyl)-cyclopropanecarboxylate

Refernces

• 1、 Yang, Zai-Bo,Li, Pei,He, Yin-Ju. "Novel pyrethrin derivatives containing hydrazone and 1,3,4-oxadiazole thioether moieties: Design, synthesis, and insecticidal activity". . p. 614 - 619. Retrieved 2020.