4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-methyl-6-(phenylseleno)-2-thioxo-

Base Information

Chemical Name:4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-methyl-6-(phenylseleno)-2-thioxo-
CAS No.:136632-07-0
Molecular Formula:C14H16N2O3SSe
Molecular Weight:371.3134
Hs Code.:
DSSTox Substance ID:DTXSID00159865
Nikkaji Number:J448.805I
ChEMBL ID:CHEMBL113581

Synonyms:CHEMBL113581;136632-07-0;4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-methyl-6-(phenylseleno)-2-thioxo-;4(1H)-Pyrimidinone, 2,3-dihydro-1-[(2-hydroxyethoxy)methyl]-5-methyl-6-(phenylseleno)-2-thioxo-;SCHEMBL9596822;DTXSID00159865;BDBM50008010;1,2-Dihydro-1-(2-hydroxyethoxymethyl)-5-methyl-6-phenylseleno-2-thioxopyrimidin-4(3H)-one;1-(2-hydroxyethoxymethyl)-5-methyl-6-phenylselanyl-2-thioxo-pyrimidin-4-one;1-(2-Hydroxy-ethoxymethyl)-5-methyl-6-phenylselanyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Suppliers and Price of 4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-methyl-6-(phenylseleno)-2-thioxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-methyl-6-(phenylseleno)-2-thioxo-

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:372.00469
Heavy Atom Count:21
Complexity:436

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(N(C(=S)NC1=O)COCCO)[Se]C2=CC=CC=C2

Technology Process of 4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-methyl-6-(phenylseleno)-2-thioxo-

There total 4 articles about 4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-methyl-6-(phenylseleno)-2-thioxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 136632-01-4
1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylselenenyl)-2-thiothymine

: 136632-07-0
1-<(2-hydroxyethoxy)methyl>-6-(phenylselenenyl)-2-thiothymine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h; Ambient temperature;
DOI:10.1021/jm00115a022

Reference yield:

: 1666-13-3
diphenyl diselenide

: 136632-07-0
1-<(2-hydroxyethoxy)methyl>-6-(phenylselenenyl)-2-thiothymine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, from -78 deg C to -70 deg C, 1 h, 2.) THF, -78 deg C, 30 min

2: 83 percent / n-Bu₄NF / tetrahydrofuran / 0.5 h / Ambient temperature

With tetrabutyl ammonium fluoride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jm00115a022

Reference yield:

: 132885-30-4
1-<(2-hydroxyethoxy)methyl>-2-thiothymine

: 136632-07-0
1-<(2-hydroxyethoxy)methyl>-6-(phenylselenenyl)-2-thiothymine

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / imidazole / dimethylformamide / Ambient temperature

2: 1.) LDA / 1.) THF, from -78 deg C to -70 deg C, 1 h, 2.) THF, -78 deg C, 30 min

3: 83 percent / n-Bu₄NF / tetrahydrofuran / 0.5 h / Ambient temperature

With 1H-imidazole; tetrabutyl ammonium fluoride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00115a022