Phenylalanine, 2-chloro-, methyl ester

Base Information

• Chemical Name: Phenylalanine, 2-chloro-, methyl ester
• CAS No.: 113961-63-0
• Molecular Formula: C10H12ClNO2
• Molecular Weight: 213.664
• Mol file: 113961-63-0.mol

Synonyms:

Chemical Property of Phenylalanine, 2-chloro-, methyl ester

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenylalanine, 2-chloro-, methyl ester

There total 2 articles about Phenylalanine, 2-chloro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(E)-methyl 3-(2-chlorophenyl)-2-(hydroxyimino)propanoate (1612831-65-8) → methyl 2-amino-3-(2-chlorophenyl)propanoate (113961-63-0)

Guidance literature:

With iron; zinc; In formic acid; at 50 - 65 ℃; for 2h;

DOI:10.1039/c3gc42432d

Reference yield:

2-chlorobenzenediazonium tetrafluoroborate (1956-97-4) → methyl 2-amino-3-(2-chlorophenyl)propanoate (113961-63-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate; acetic acid; ferrous(II) sulfate heptahydrate; nitrogen / dimethyl sulfoxide; water / 0.08 h

2: iron; zinc / formic acid / 2 h / 50 - 65 °C

With ferrous(II) sulfate heptahydrate; nitrogen; sodium acetate; iron; acetic acid; zinc; In formic acid; water; dimethyl sulfoxide; 1: |Meerwein Arylation;

DOI:10.1039/c3gc42432d

upstream raw materials:

(E)-methyl 3-(2-chlorophenyl)-2-(hydroxyimino)propanoate

2-chlorobenzenediazonium tetrafluoroborate

Refernces