2-Cyclobuten-1-one, 4-hydroxy-2,3-dimethoxy-4-(3-phenyl-1-propynyl)-

Base Information

• Chemical Name: 2-Cyclobuten-1-one, 4-hydroxy-2,3-dimethoxy-4-(3-phenyl-1-propynyl)-
• CAS No.: 113976-71-9
• Molecular Formula: C15H14O4
• Molecular Weight: 258.274
• DSSTox Substance ID: DTXSID00438288
• Nikkaji Number: J595.333B
• Mol file: 113976-71-9.mol

Synonyms:113976-71-9;2-Cyclobuten-1-one, 4-hydroxy-2,3-dimethoxy-4-(3-phenyl-1-propynyl)-;DTXSID00438288

Chemical Property of 2-Cyclobuten-1-one, 4-hydroxy-2,3-dimethoxy-4-(3-phenyl-1-propynyl)-

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 258.08920892
• Heavy Atom Count: 19
• Complexity: 459

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(C1=O)(C#CCC2=CC=CC=C2)O)OC

Technology Process of 2-Cyclobuten-1-one, 4-hydroxy-2,3-dimethoxy-4-(3-phenyl-1-propynyl)-

There total 2 articles about 2-Cyclobuten-1-one, 4-hydroxy-2,3-dimethoxy-4-(3-phenyl-1-propynyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(3-phenylprop-1-ynyl)lithium (102683-42-1) + 3,4-dimethoxy-3-cyclobutene-1,2-dione (5222-73-1) → 2,3-dimethoxy-4-hydroxy-4-(3-phenyl-1-propynyl)-2-cyclobuten-1-one (113976-71-9)

Guidance literature:

In tetrahydrofuran; at -78 ℃;

DOI:10.1016/0040-4039(88)85284-5

Reference yield:

propargyl benzene (10147-11-2) + 3,4-dimethoxy-3-cyclobutene-1,2-dione (5222-73-1) → 2,3-dimethoxy-4-hydroxy-4-(3-phenyl-1-propynyl)-2-cyclobuten-1-one (113976-71-9)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; THF, -78 deg C;

DOI:10.1021/ja00185a030

Reference yield: 80.0%

2,3-dimethoxy-4-hydroxy-4-(3-phenyl-1-propynyl)-2-cyclobuten-1-one (113976-71-9) → 3-methoxy-4-(3-phenyl-1-propynyl)-3-cyclobutene-1,2-dione (113976-83-3)

Guidance literature:

With pyridine; thionyl chloride; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

DOI:10.1021/jo00246a016

upstream raw materials:

propargyl benzene

3,4-dimethoxy-3-cyclobutene-1,2-dione

(3-phenylprop-1-ynyl)lithium

Downstream raw materials:

2-(3-phenyl-1-propynyl)-3,4,4-trimethoxy-2-cyclobuten-1-one

(E)-4-(Butenyloxy)-2,3-dimethoxy-4-(3-phenyl-1-propynyl)-2-cyclobuten-1-one

2,3-Dimethoxy-4-(3-phenyl-1-propynyl)-4-(2-propenyloxy)-2-cyclobuten-1-one

2,3-Dimethoxy-4-(3-phenoxy-1-propynyl)-4-(2-hexynyloxy)-2-cyclobuten-1-one

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