Levovirin

Base Information

Chemical Name:Levovirin
CAS No.:206269-27-4
Molecular Formula:C8H12 N4 O5
Molecular Weight:244.207
Hs Code.:
UNII:ZGF0S6S33Q
DSSTox Substance ID:DTXSID90174648
Nikkaji Number:J1.303.803A
Wikidata:Q27295481
Metabolomics Workbench ID:149818
ChEMBL ID:CHEMBL274536
Mol file:206269-27-4.mol

Synonyms:Levovirin;206269-27-4;L-Ribavirin;ICN17261;ICN 17261;ICN-17261;UNII-ZGF0S6S33Q;ZGF0S6S33Q;1-((2S,3S,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxamide;1H-1,2,4-Triazole-3-carboxamide, 1-beta-L-ribofuranosyl-;1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide;LEVOVIRIN [WHO-DD];SCHEMBL427229;CHEMBL274536;DTXSID90174648;1-[(2S,3S,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide;CCG-55669;AKOS040747072;DB06523;LS-186117;J-013473;1-beta-L-Ribofuranosyl-1,2,4-triazole-3-carboxamide;BRD-K30829421-001-01-0;Q27295481;1-beta-l-ribofuranosyl-1h-1,2,4-triazole-3-carboxamide;1H-1,2,4-Triazole-3-carboxamide, 1-.beta.-L-ribofuranosyl-;1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE, 1-BETA;-L-RIBOFURANOSYL-;1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,2,4-triazole-3-carboxamide

Suppliers and Price of Levovirin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Levovirin
100mg
$ 1325.00

TRC
Levovirin
10mg
$ 170.00

Medical Isotopes, Inc.
Levovirin
100 mg
$ 2400.00

Medical Isotopes, Inc.
Levovirin
10 mg
$ 675.00

American Custom Chemicals Corporation
1-BETA-L-RIBOFURANOSYL-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE 95.00%
10MG
$ 601.52

Total 33 raw suppliers

Chemical Property of Levovirin

Chemical Property:

Vapor Pressure:3.03E-17mmHg at 25°C
Boiling Point:639.8°Cat760mmHg
Flash Point:340.7°C
PSA：143.72000
Density:2.08g/cm³
LogP:-2.31120
XLogP3:-1.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:244.08076950
Heavy Atom Count:17
Complexity:304

Purity/Quality:

99% ^*data from raw suppliers

Levovirin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
Isomeric SMILES:C1=NC(=NN1[C@@H]2[C@H]([C@H]([C@@H](O2)CO)O)O)C(=O)N
Uses Levovirin is a monocyclic L-nucleosides with type 1 cytokine-inducing activity. Levovirin is the L-enantiomer of Ribavirin (R414475) with similar immunomodulatory activity but does not have direct antiviral activity or hemolytic anemia.

Technology Process of Levovirin

There total 3 articles about Levovirin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 206269-26-3
methyl 1-(2,3,5-tri-O-acetyl-β-L-ribofuranosyl)-1,2,4-triazole-3-carboxylate

: 206269-27-4,66510-90-5
ribavirin

Guidance literature:: With methanol; ammonia; at 20 ℃; for 18h;
DOI:10.1021/jm9905514

Reference yield:

: 41546-21-8
L-ribose

: 206269-27-4,66510-90-5
ribavirin

Guidance literature:: Multi-step reaction with 3 steps

1.1: HCl / methanol / 3 h / 20 °C

1.2: pyridine / 24 h / 20 °C

1.3: 60 percent / glacial AcOH; conc. H₂SO₄ / 14 h / 20 °C

2.1: 84 percent / bis(p-nitrophenyl)phosphate / 0.42 h / 165 - 175 °C

3.1: 89 percent / NH₃/MeOH / 18 h / 20 °C

With hydrogenchloride; methanol; Bis(p-nitrophenyl) phosphate; ammonia; In methanol; 1.1: Acetylation / 1.2: Acetylation / 1.3: Acetylation / 2.1: Condensation / 3.1: Hydrolysis;
DOI:10.1021/jm9905514

Reference yield:

: 144490-03-9
1,2,3,5-tetra-O-acetyl-β-L-ribofuranose

: 206269-27-4,66510-90-5
ribavirin

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / bis(p-nitrophenyl)phosphate / 0.42 h / 165 - 175 °C

2: 89 percent / NH₃/MeOH / 18 h / 20 °C

With methanol; Bis(p-nitrophenyl) phosphate; ammonia; 1: Condensation / 2: Hydrolysis;
DOI:10.1021/jm9905514