Indolaprilat

Base Information

Chemical Name:Indolaprilat
CAS No.:80828-34-8
Molecular Formula:C₂₂H₃₀N₂O₅
Molecular Weight:402.491
Hs Code.:
UNII:549IN39U0T
ChEMBL ID:CHEMBL3349972
DSSTox Substance ID:DTXSID20230645
Nikkaji Number:J528.984J
Wikidata:Q27261195

Synonyms:Indolaprilat;Indolapril diacid;UNII-549IN39U0T;549IN39U0T;80828-34-8;CHEMBL3349972;1H-Indole-2-carboxylic acid, 1-((2S)-2-(((1S)-1-carboxy-3-phenylpropyl)amino)-1-oxopropyl)octahydro-, (2S,3aS,7aS)-;SCHEMBL683838;DTXSID20230645;BDBM50226811;Q27261195

Suppliers and Price of Indolaprilat

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Indolaprilat

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:402.21547206
Heavy Atom Count:29
Complexity:604

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)N1C2CCCCC2CC1C(=O)O)NC(CCC3=CC=CC=C3)C(=O)O
Isomeric SMILES:C[C@@H](C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O)N[C@@H](CCC3=CC=CC=C3)C(=O)O

Technology Process of Indolaprilat

There total 6 articles about Indolaprilat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80828-13-3,80875-98-5,82717-40-6,87679-20-7,87679-39-8,87679-51-4,87679-58-1,88547-85-7,88585-94-8,96844-78-9,108507-42-2,145438-94-4,145438-95-5,145513-90-2,145513-91-3,145513-92-4,145513-93-5,2055118-14-2
(+/-)-(2S,3aS,7aS)-octahydroindole-2-carboxylic acid

: 80828-34-8
Indolapril diacid

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / conc. H₂SO₄ / dioxane / 20 h / 20 °C

3: 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / a) 0 deg C, 1 h, b) RT, overnight

4: 93 percent / HCl(g) / CH₂Cl₂ / 0 °C

5: 1.4N NaOH / H₂O / Ambient temperature

With hydrogenchloride; sodium hydroxide; sulfuric acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jm00389a006

Reference yield:

: 3770-50-1,117770-52-2
2-carbethoxyindole

: 80828-34-8
Indolapril diacid

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / Rh/C / acetic acid

2: aq. 15percent HCl / 4 h / Heating

3: 76 percent / conc. H₂SO₄ / dioxane / 20 h / 20 °C

5: 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / a) 0 deg C, 1 h, b) RT, overnight

6: 93 percent / HCl(g) / CH₂Cl₂ / 0 °C

7: 1.4N NaOH / H₂O / Ambient temperature

With hydrogenchloride; sodium hydroxide; sulfuric acid; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; Rh on carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetic acid;
DOI:10.1021/jm00389a006