1H-Pyrrole-3-propanoic acid, 2,5-dihydro-4-(2-methoxy-2-oxoethyl)-5-[[3-(2-methoxy-2-oxoethyl)-4-(3- methoxy-3-oxopropyl)-5-[(phenylmethoxy)carbonyl]-1H-pyrrol-2-yl]methyl ]-5-methyl-2-oxo-, methyl ester

Base Information

• Chemical Name: 1H-Pyrrole-3-propanoic acid, 2,5-dihydro-4-(2-methoxy-2-oxoethyl)-5-[[3-(2-methoxy-2-oxoethyl)-4-(3- methoxy-3-oxopropyl)-5-[(phenylmethoxy)carbonyl]-1H-pyrrol-2-yl]methyl ]-5-methyl-2-oxo-, methyl ester
• CAS No.: 114091-93-9
• Molecular Formula: C32H38N2O11
• Molecular Weight: 626.661
• Mol file: 114091-93-9.mol

Synonyms:

Chemical Property of 1H-Pyrrole-3-propanoic acid, 2,5-dihydro-4-(2-methoxy-2-oxoethyl)-5-[[3-(2-methoxy-2-oxoethyl)-4-(3- methoxy-3-oxopropyl)-5-[(phenylmethoxy)carbonyl]-1H-pyrrol-2-yl]methyl ]-5-methyl-2-oxo-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-3-propanoic acid, 2,5-dihydro-4-(2-methoxy-2-oxoethyl)-5-[[3-(2-methoxy-2-oxoethyl)-4-(3- methoxy-3-oxopropyl)-5-[(phenylmethoxy)carbonyl]-1H-pyrrol-2-yl]methyl ]-5-methyl-2-oxo-, methyl ester

There total 5 articles about 1H-Pyrrole-3-propanoic acid, 2,5-dihydro-4-(2-methoxy-2-oxoethyl)-5-[[3-(2-methoxy-2-oxoethyl)-4-(3- methoxy-3-oxopropyl)-5-[(phenylmethoxy)carbonyl]-1H-pyrrol-2-yl]methyl ]-5-methyl-2-oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-[5-Chloro-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-2-methyl-2H-pyrrol-2-ylmethyl]-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester (114125-36-9) → 3-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylmethyl]-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester (114091-93-9)

Guidance literature:

With silver(I) acetate; toluene-4-sulfonic acid; In tetrahydrofuran; water;

DOI:10.1039/c39870001313

Reference yield:

3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-5-methyl-pyrrole-2-carboxylic acid (72423-56-4) → 3-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylmethyl]-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester (114091-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: KI, I₂, NaHCO₃ / CH₂Cl₂; H₂O / 0.03 h

2: 1.) SnCl₄, 2.) SmI₂ / 1.) CH₂Cl₂, -78 to 0 deg C, 3 h, 2.) CH₂Cl₂, THF, -78 deg C to r.t., 1 h

With samarium diiodide; iodine; tin(IV) chloride; sodium hydrogencarbonate; potassium iodide; In dichloromethane; water;

DOI:10.1039/a708132d

Reference yield:

5-acetoxymethyl-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-pyrrole-2-carboxylic acid benzyl ester (50622-67-8) → 3-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylmethyl]-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester (114091-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / SnCl₄ / CH₂Cl₂

2: 84 percent / AgOAc, p-MeC₆H₄SO₃H / tetrahydrofuran; H₂O

With silver(I) acetate; tin(IV) chloride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; water;

DOI:10.1039/c39870001313

upstream raw materials:

5-acetoxymethyl-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-pyrrole-2-carboxylic acid benzyl ester

3-(2-Iodo-4-methoxycarbonylmethyl-5-methyl-1H-pyrrol-3-yl)-propionic acid methyl ester

5-[5-Chloro-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-2-methyl-2H-pyrrol-2-ylmethyl]-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-5-methyl-pyrrole-2-carboxylic acid

Downstream raw materials:

3-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-2-methyl-5-thioxo-2,5-dihydro-1H-pyrrol-2-ylmethyl]-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

Benzyl 2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4-methyl-10-nitroso-1,4,5,10-tetrahydro-1-oxodipyrrin-9-carboxylate

5-[5-Chloro-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-2-methyl-2H-pyrrol-2-ylmethyl]-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

2-[5-Benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethylpyrrol-2-ylmethyl]-4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethyl-2-methyl-2H-pyrrole

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