N~2~-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)lysine

Base Information

Chemical Name:N~2~-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)lysine
CAS No.:51865-81-7
Molecular Formula:C21H27 N9 O3 . 3 Br H
Molecular Weight:453.4976
Hs Code.:
Mol file:51865-81-7.mol

Synonyms:NCI 127977;NSC 127977

Suppliers and Price of N~2~-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)lysine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of N~2~-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)lysine

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.411g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N~2~-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)lysine

There total 4 articles about N~2~-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 80407-75-6
N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine tert-butyl ester

: 51865-81-7
N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-lysine hydrobromide

Guidance literature:: With boron tribromide; In dichloromethane; 1.) -10 deg C, 1 h, 2.) 25 deg C, 2 h;
DOI:10.1021/jm00346a026

Reference yield:

: 56892-71-8
4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride

: 51865-81-7
N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-lysine hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine / 1 h / 60 °C

2: 41 percent / 1 M BBr₃ / CH₂Cl₂ / 1.) -10 deg C, 1 h, 2.) 25 deg C, 2 h

With 4-methyl-morpholine; boron tribromide; In dichloromethane;
DOI:10.1021/jm00346a026

Reference yield:

: 19741-14-1
4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

: 51865-81-7
N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-lysine hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine / various solvent(s) / 0.33 h / 0 °C

2: N-methylmorpholine / 1 h / 60 °C

3: 41 percent / 1 M BBr₃ / CH₂Cl₂ / 1.) -10 deg C, 1 h, 2.) 25 deg C, 2 h

With 4-methyl-morpholine; boron tribromide; In dichloromethane;
DOI:10.1021/jm00346a026