Isoxazolo[5,4-b]pyridine, 7-benzoyl-4,5,6,7-tetrahydro-3-phenyl-5-(1-pyrrolidinylmethyl)-, monohydrochloride

Base Information

• Chemical Name: Isoxazolo[5,4-b]pyridine, 7-benzoyl-4,5,6,7-tetrahydro-3-phenyl-5-(1-pyrrolidinylmethyl)-, monohydrochloride
• CAS No.: 114193-64-5
• Molecular Formula: C24H25N3O2.ClH
• Molecular Weight: 423.942
• Mol file: 114193-64-5.mol

Synonyms:

Chemical Property of Isoxazolo[5,4-b]pyridine, 7-benzoyl-4,5,6,7-tetrahydro-3-phenyl-5-(1-pyrrolidinylmethyl)-, monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isoxazolo[5,4-b]pyridine, 7-benzoyl-4,5,6,7-tetrahydro-3-phenyl-5-(1-pyrrolidinylmethyl)-, monohydrochloride

There total 6 articles about Isoxazolo[5,4-b]pyridine, 7-benzoyl-4,5,6,7-tetrahydro-3-phenyl-5-(1-pyrrolidinylmethyl)-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzoylacetonitrile (614-16-4) → 7-benzoyl-3-phenyl-5-pyrrolidinomethyl-4,5,6,7-tetrahydroisoxazolo<5,4-b>pyridine hydrochloride (114193-64-5)

Guidance literature:

Multi-step reaction with 7 steps

1: ethanol / 8 h / Heating

2: NH₂OH*HCl,pyridine / 4 h / Heating

3: NaOMe / methanol / 1.5 h / Heating

4: 11.6 percent / NaBH₄, LiBr / 1,2-dimethoxy-ethane / 5 h / Ambient temperature

5: 56.6 percent / pyridine / 13 h / Ambient temperature

6: pyrrolidine / 3 h / Heating

7: 40.4 percent / pyridine, aq.HCl / Ambient temperature

With pyrrolidine; pyridine; hydrogenchloride; sodium tetrahydroborate; hydroxylamine hydrochloride; sodium methylate; lithium bromide; In methanol; 1,2-dimethoxyethane; ethanol;

DOI:10.1248/cpb.35.3676

Reference yield:

5-ethoxycarbonyl-6-oxo-3-phenyl-4,5,6,7-tetrahydroisoxazolo<5,4-b>pyridine (114193-42-9) → 7-benzoyl-3-phenyl-5-pyrrolidinomethyl-4,5,6,7-tetrahydroisoxazolo<5,4-b>pyridine hydrochloride (114193-64-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 11.6 percent / NaBH₄, LiBr / 1,2-dimethoxy-ethane / 5 h / Ambient temperature

2: 56.6 percent / pyridine / 13 h / Ambient temperature

3: pyrrolidine / 3 h / Heating

4: 40.4 percent / pyridine, aq.HCl / Ambient temperature

With pyrrolidine; pyridine; hydrogenchloride; sodium tetrahydroborate; lithium bromide; In 1,2-dimethoxyethane;

DOI:10.1248/cpb.35.3676

Reference yield:

2-(2-Cyano-3-oxo-3-phenyl-propyl)-malonic acid diethyl ester (114193-58-7) → 7-benzoyl-3-phenyl-5-pyrrolidinomethyl-4,5,6,7-tetrahydroisoxazolo<5,4-b>pyridine hydrochloride (114193-64-5)

Guidance literature:

Multi-step reaction with 6 steps

1: NH₂OH*HCl,pyridine / 4 h / Heating

2: NaOMe / methanol / 1.5 h / Heating

3: 11.6 percent / NaBH₄, LiBr / 1,2-dimethoxy-ethane / 5 h / Ambient temperature

4: 56.6 percent / pyridine / 13 h / Ambient temperature

5: pyrrolidine / 3 h / Heating

6: 40.4 percent / pyridine, aq.HCl / Ambient temperature

With pyrrolidine; pyridine; hydrogenchloride; sodium tetrahydroborate; hydroxylamine hydrochloride; sodium methylate; lithium bromide; In methanol; 1,2-dimethoxyethane;

DOI:10.1248/cpb.35.3676

upstream raw materials:

Benzoylacetonitrile

5-hydroxymethyl-3-phenyl-4,5,6,7-tetrahydroisoxazolo<5,4-b>pyridine

5-ethoxycarbonyl-6-oxo-3-phenyl-4,5,6,7-tetrahydroisoxazolo<5,4-b>pyridine

2-(2-Cyano-3-oxo-3-phenyl-propyl)-malonic acid diethyl ester

Downstream raw materials:

7-benzyl-3-phenyl-5-pyrrolidinomethyl-4,5,6,7-tetrahydroisoxazolo<5,4-b>pyridine hydrochloride

7-benzyl-3-phenyl-5-pyrrolidinomethyl-4,5,6,7-tetrahydroisoxazolo<5,4-b>pyridine