Isoxazolo[5,4-b]pyridine, 4,5,6,7-tetrahydro-3-phenyl-7-(phenylmethyl)-5-(1-pyrrolidinylmethyl)-, monohydrochloride

Base Information

Chemical Name:Isoxazolo[5,4-b]pyridine, 4,5,6,7-tetrahydro-3-phenyl-7-(phenylmethyl)-5-(1-pyrrolidinylmethyl)-, monohydrochloride
CAS No.:114193-65-6
Molecular Formula:C24H27N3O.ClH
Molecular Weight:409.959
Hs Code.:

Synonyms:

Suppliers and Price of Isoxazolo[5,4-b]pyridine, 4,5,6,7-tetrahydro-3-phenyl-7-(phenylmethyl)-5-(1-pyrrolidinylmethyl)-, monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Isoxazolo[5,4-b]pyridine, 4,5,6,7-tetrahydro-3-phenyl-7-(phenylmethyl)-5-(1-pyrrolidinylmethyl)-, monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Isoxazolo[5,4-b]pyridine, 4,5,6,7-tetrahydro-3-phenyl-7-(phenylmethyl)-5-(1-pyrrolidinylmethyl)-, monohydrochloride

There total 9 articles about Isoxazolo[5,4-b]pyridine, 4,5,6,7-tetrahydro-3-phenyl-7-(phenylmethyl)-5-(1-pyrrolidinylmethyl)-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

: 114193-64-5
7-benzoyl-3-phenyl-5-pyrrolidinomethyl-4,5,6,7-tetrahydroisoxazolo<5,4-b>pyridine hydrochloride

: 114193-65-6
7-benzyl-3-phenyl-5-pyrrolidinomethyl-4,5,6,7-tetrahydroisoxazolo<5,4-b>pyridine hydrochloride

Guidance literature:: With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; for 5h; Ambient temperature;
DOI:10.1248/cpb.35.3676

Reference yield:

: 614-16-4
Benzoylacetonitrile

: 114193-65-6
7-benzyl-3-phenyl-5-pyrrolidinomethyl-4,5,6,7-tetrahydroisoxazolo<5,4-b>pyridine hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: ethanol / 8 h / Heating

2: NH₂OH*HCl,pyridine / 4 h / Heating

3: NaOMe / methanol / 1.5 h / Heating

4: 11.6 percent / NaBH₄, LiBr / 1,2-dimethoxy-ethane / 5 h / Ambient temperature

5: 56.6 percent / pyridine / 13 h / Ambient temperature

6: pyrrolidine / 3 h / Heating

7: 40.4 percent / pyridine, aq.HCl / Ambient temperature

8: 74.6 percent / LiAlH₄, HCl-gas / tetrahydrofuran / 5 h / Ambient temperature

With pyrrolidine; pyridine; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium methylate; lithium bromide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol;
DOI:10.1248/cpb.35.3676

Reference yield:

: 114193-42-9
5-ethoxycarbonyl-6-oxo-3-phenyl-4,5,6,7-tetrahydroisoxazolo<5,4-b>pyridine

: 114193-65-6
7-benzyl-3-phenyl-5-pyrrolidinomethyl-4,5,6,7-tetrahydroisoxazolo<5,4-b>pyridine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 11.6 percent / NaBH₄, LiBr / 1,2-dimethoxy-ethane / 5 h / Ambient temperature

2: 56.6 percent / pyridine / 13 h / Ambient temperature

3: pyrrolidine / 3 h / Heating

4: 40.4 percent / pyridine, aq.HCl / Ambient temperature

5: 74.6 percent / LiAlH₄, HCl-gas / tetrahydrofuran / 5 h / Ambient temperature

With pyrrolidine; pyridine; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; lithium bromide; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1248/cpb.35.3676