5'-Deoxy-5-fluorouridine 2',3'-diacetate

Base Information

Chemical Name:5'-Deoxy-5-fluorouridine 2',3'-diacetate
CAS No.:76462-82-3
Molecular Formula:C13H15 F N2 O7
Molecular Weight:330.27
Hs Code.:
European Community (EC) Number:278-472-4
Nikkaji Number:J319.330F

Synonyms:5'-Deoxy-5-fluorouridine 2',3'-diacetate;76462-82-3;EINECS 278-472-4;SCHEMBL11134817;ONKMZOUZXRFSQO-RPULLILYSA-N;NS00058750;1-(5-deoxy-2,3-di-O-acetyl-beta-D-ribofuranosyl)-5-fluorouracil;(2R,3R,4R,5R)-2-(5-Fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5-methyltetrahydrofuran-3,4-diyl diacetate

Suppliers and Price of 5'-Deoxy-5-fluorouridine 2',3'-diacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 12 raw suppliers

Chemical Property of 5'-Deoxy-5-fluorouridine 2',3'-diacetate

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.45g/cm³
XLogP3:-0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:330.08632898
Heavy Atom Count:23
Complexity:591

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(C(C(O1)N2C=C(C(=O)NC2=O)F)OC(=O)C)OC(=O)C
Isomeric SMILES:C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=C(C(=O)NC2=O)F)OC(=O)C)OC(=O)C

Technology Process of 5'-Deoxy-5-fluorouridine 2',3'-diacetate

There total 21 articles about 5'-Deoxy-5-fluorouridine 2',3'-diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 51-21-8
5-fluorouracil

: C₂₄H₂₄O₇

: 76462-82-3
1-(5-Deoxy-2,3-di-O-acetyl-β-D-ribofuranosyl)-5-fluor-uracil

Guidance literature:: 5-fluorouracil; With N,O-Bis(trimethylsilyl)trifluoroacetamide; In acetonitrile; at 50 ℃; for 0.5h; Inert atmosphere;

C₂₄H₂₄O₇; In acetonitrile; at 20 ℃; for 0.75h; Inert atmosphere; Molecular sieve;

With N-iodo-succinimide; trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 0 - 20 ℃; for 2h; Inert atmosphere; Molecular sieve;

Reference yield: 92.0%

: 17242-85-2
5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine

: 27821-07-4,27930-18-3,37076-71-4,62211-93-2,63903-44-6,76497-54-6
1,2,3-tri-O-acetyl-5-deoxy-β-D-ribofuranose

: C₂₂H₂₇FN₂O₁₂

: 76462-82-3
1-(5-Deoxy-2,3-di-O-acetyl-β-D-ribofuranosyl)-5-fluor-uracil

Guidance literature:: With 2,6-di-tert-butyl-4-methylpyridinium trifluoromethanesulfonate; In acetonitrile; at 80 ℃;
DOI:10.1021/ol301324g

Reference yield: 65.0%

: 37076-71-4
5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose

: 51-21-8
5-fluoropyrimidine-2,4-diol

: 76462-83-4
1-(5-Deoxy-2,3-di-O-acetyl-α-D-ribofuranosyl)-5-fluor-uracil

: 76462-82-3
1-(5-Deoxy-2,3-di-O-acetyl-β-D-ribofuranosyl)-5-fluor-uracil

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; for 20h; Yields of byproduct given; Ambient temperature;
DOI:10.1002/hlca.19820650525