5,7-Dihydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxofuro(3,4-b)pyridine-3-carbonitrile

Base Information

Chemical Name:5,7-Dihydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxofuro(3,4-b)pyridine-3-carbonitrile
CAS No.:126335-09-9
Molecular Formula:C₁₆H₁₀F₂N₂O₃
Molecular Weight:316.264
Hs Code.:
DSSTox Substance ID:DTXSID50155150
Wikidata:Q83022870
Mol file:126335-09-9.mol

Synonyms:126335-09-9;BRN 4270244;5,7-Dihydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxofuro(3,4-b)pyridine-3-carbonitrile;4-[2-(difluoromethoxy)phenyl]-2-methyl-5-oxo-7H-furo[3,4-b]pyridine-3-carbonitrile;Furo(3,4-b)pyridine-3-carbonitrile, 5,7-dihydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxo-;5-[2-(difluoromethoxy)phenyl]-3-methyl-7-oxo-8-oxa-2-azabicyclo[4.3.0] nona-1,3,5-triene-4-carbonitr;DTXSID50155150;C16H10F2N2O3;MGLSVVFTWODJSS-UHFFFAOYSA-N;LS-70880

Suppliers and Price of 5,7-Dihydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxofuro(3,4-b)pyridine-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5,7-Dihydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxofuro(3,4-b)pyridine-3-carbonitrile

Chemical Property:

Vapor Pressure:8.15E-10mmHg at 25°C
Boiling Point:491.8°Cat760mmHg
Flash Point:251.2°C
PSA：72.21000
Density:1.45g/cm³
LogP:3.20048
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:316.06594851
Heavy Atom Count:23
Complexity:507

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=C2C(=N1)COC2=O)C3=CC=CC=C3OC(F)F)C#N

Technology Process of 5,7-Dihydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxofuro(3,4-b)pyridine-3-carbonitrile

There total 2 articles about 5,7-Dihydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxofuro(3,4-b)pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 92638-16-9
2-methyl-3-cyano-4-(2'-difluoromethoxyphenyl)-5-oxo-1,4,5,7-tetrahydrofuro<3,4-b>pyridine

: 126335-09-9
4-(2-Difluoromethoxy-phenyl)-2-methyl-5-oxo-5,7-dihydro-furo[3,4-b]pyridine-3-carbonitrile

Guidance literature:: With nitric acid; at 70 - 80 ℃; for 1h;
DOI:10.1007/BF00764614

Reference yield:

: 100507-47-9
2,6-dimethyl-3-cyano-4-(2'-difluoromethoxyphenyl)-5-methoxycarbonyl-1,4-dihydropyridine

: 126335-09-9
4-(2-Difluoromethoxy-phenyl)-2-methyl-5-oxo-5,7-dihydro-furo[3,4-b]pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 33 percent / N-bromosuccinimide (NBS) / CHCl₃ / 0.5 h / Heating

2: 74 percent / 3 N nitric acid / 1 h / 70 - 80 °C

With N-Bromosuccinimide; nitric acid; In chloroform;
DOI:10.1007/BF00764614