Ethyl thiazolo[5,4-c]pyridine-2-carboxylate

Base Information

• Chemical Name: Ethyl thiazolo[5,4-c]pyridine-2-carboxylate
• CAS No.: 114498-58-7
• Molecular Formula: C₉H₈N₂O₂S
• Molecular Weight: 208.241
• Hs Code.: 2934999090
• Mol file: 114498-58-7.mol

Synonyms:Thiazolo[5,4-c]pyridine-2-carboxylic acid,ethyl ester;Ethyl thiazolo[5,4-c]pyridine-2-carboxylate;

Chemical Property of Ethyl thiazolo[5,4-c]pyridine-2-carboxylate

Chemical Property:

• Melting Point: 102-105 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
• Boiling Point: 339.5±34.0 °C(Predicted)
• PKA: 1.09±0.50(Predicted)
• PSA: 80.32000
• Density: 1.353±0.06 g/cm3(Predicted)
• LogP: 1.86800
• Storage Temp.: 2-8°C

Purity/Quality:

Ethylthiazolo[5,4-c]pyridine-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl thiazolo[5,4-c]pyridine-2-carboxylate

There total 4 articles about Ethyl thiazolo[5,4-c]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

<<3-<<(diethylamino)thioxomethyl>thio>-4-pyridinyl>amino>oxoacetic acid ethyl ester (129333-23-9) → thiazolo<5,4-c>pyridine-2-carboxylic acid ethyl ester (114498-58-7)

Guidance literature:

With formic acid; for 3h; Heating;

DOI:10.1002/jhet.5570270316

Reference yield:

<4-amino-3-pyridinyl>diethylcarbamodithioate (129333-21-7) → thiazolo<5,4-c>pyridine-2-carboxylic acid ethyl ester (114498-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / Et₃N / acetone / 68 h / Ambient temperature

2: 34 percent / 98percent HCOOH / 3 h / Heating

With formic acid; triethylamine; In acetone;

DOI:10.1002/jhet.5570270316

Reference yield:

<4-<(2,2-dimethyl-1-oxopropyl)amino>-3-pyridinyl>diethylcarbamodithioate (129333-20-6) → thiazolo<5,4-c>pyridine-2-carboxylic acid ethyl ester (114498-58-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 36 percent / 1 N NaOH / methanol / 2 h / Ambient temperature

2: 35 percent / Et₃N / acetone / 68 h / Ambient temperature

3: 34 percent / 98percent HCOOH / 3 h / Heating

With sodium hydroxide; formic acid; triethylamine; In methanol; acetone;

DOI:10.1002/jhet.5570270316

upstream raw materials:

<<3-<<(diethylamino)thioxomethyl>thio>-4-pyridinyl>amino>oxoacetic acid ethyl ester

<4-amino-3-pyridinyl>diethylcarbamodithioate

<4-<(2,2-dimethyl-1-oxopropyl)amino>-3-pyridinyl>diethylcarbamodithioate

4-N-pivaloylaminopyridine

Downstream raw materials:

Thiazolo[5,4-c]pyridine-2-carboxylic acid(1(R)-phenyl-ethyl)amide

Thiazolo[5,4-c]pyridine-2-carboxylic acid(1(S)-phenyl-ethyl)amide

Refernces