2-Oxa-5,8,11-triazapentadecan-15-oic acid, 3,10-dioxo-5,8-bis[2-oxo-2-(phenylmethoxy)ethyl]-1-phenyl-

Base Information

• Chemical Name: 2-Oxa-5,8,11-triazapentadecan-15-oic acid, 3,10-dioxo-5,8-bis[2-oxo-2-(phenylmethoxy)ethyl]-1-phenyl-
• CAS No.: 114519-86-7
• Molecular Formula: C35H41N3O9
• Molecular Weight: 647.725
• Mol file: 114519-86-7.mol

Synonyms:

Chemical Property of 2-Oxa-5,8,11-triazapentadecan-15-oic acid, 3,10-dioxo-5,8-bis[2-oxo-2-(phenylmethoxy)ethyl]-1-phenyl-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Oxa-5,8,11-triazapentadecan-15-oic acid, 3,10-dioxo-5,8-bis[2-oxo-2-(phenylmethoxy)ethyl]-1-phenyl-

There total 3 articles about 2-Oxa-5,8,11-triazapentadecan-15-oic acid, 3,10-dioxo-5,8-bis[2-oxo-2-(phenylmethoxy)ethyl]-1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-(2-{Benzyloxycarbonylmethyl-[2-(bis-benzyloxycarbonylmethyl-amino)-ethyl]-amino}-acetylamino)-butyric acid tert-butyl ester (128660-10-6) → 4-(2-{Benzyloxycarbonylmethyl-[2-(bis-benzyloxycarbonylmethyl-amino)-ethyl]-amino}-acetylamino)-butyric acid (114519-86-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1021/ja00173a027

Reference yield:

4-[2-(2-Amino-ethylamino)-acetylamino]-butyric acid tert-butyl ester (128660-09-3) → 4-(2-{Benzyloxycarbonylmethyl-[2-(bis-benzyloxycarbonylmethyl-amino)-ethyl]-amino}-acetylamino)-butyric acid (114519-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / diisopropylethylamine / dimethylformamide / 1.) RT, 1 h, 2.) 35 deg C, 15 h

2: 78 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja00173a027

Reference yield:

tert-butyl N-δ-(bromoacetamido)-γ-aminobutanoate (128660-08-2) → 4-(2-{Benzyloxycarbonylmethyl-[2-(bis-benzyloxycarbonylmethyl-amino)-ethyl]-amino}-acetylamino)-butyric acid (114519-86-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / dimethylformamide / 1.) 10 deg C, 1 h, 2.) RT, 2 h

2: 81 percent / diisopropylethylamine / dimethylformamide / 1.) RT, 1 h, 2.) 35 deg C, 15 h

3: 78 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja00173a027

upstream raw materials:

4-(2-{Benzyloxycarbonylmethyl-[2-(bis-benzyloxycarbonylmethyl-amino)-ethyl]-amino}-acetylamino)-butyric acid tert-butyl ester

tert-butyl N-δ-(bromoacetamido)-γ-aminobutanoate

4-[2-(2-Amino-ethylamino)-acetylamino]-butyric acid tert-butyl ester

Refernces