6-Bromo-2,3-dimethoxyphenol

Base Information

• Chemical Name: 6-Bromo-2,3-dimethoxyphenol
• CAS No.: 114605-75-3
• Molecular Formula: C8H9BrO3
• Molecular Weight: 233.062
• European Community (EC) Number: 966-467-6
• DSSTox Substance ID: DTXSID80552951
• Wikidata: Q82433389
• Mol file: 114605-75-3.mol

Synonyms:6-Bromo-2,3-dimethoxyphenol;114605-75-3;Phenol, 6-bromo-2,3-dimethoxy-;SCHEMBL2589132;DTXSID80552951;GLFHKBHNESVSIM-UHFFFAOYSA-N;MFCD13186752;s10820;CS-0109775;EN300-3212056

Chemical Property of 6-Bromo-2,3-dimethoxyphenol

Chemical Property:

• PSA: 38.69000
• LogP: 2.17190
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 231.97351
• Heavy Atom Count: 12
• Complexity: 142

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-2,3-dimethoxyphenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=C(C=C1)Br)O)OC

Technology Process of 6-Bromo-2,3-dimethoxyphenol

There total 11 articles about 6-Bromo-2,3-dimethoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,3-dimethoxyphenol (5150-42-5) → 6-bromo-2,3-dimethoxyphenol (114605-75-3)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; at -78 - 20 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/ja207835w

Reference yield: 91.0%

6-bromo-2,3-dimethoxyphenyl toluene-p-sulphonate (135678-35-2) → 6-bromo-2,3-dimethoxyphenol (114605-75-3)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 50 ℃; for 5h;

Reference yield: 81.0%

1-bromo-2-isopropoxy-3,4-dimethoxybenzene → 6-bromo-2,3-dimethoxyphenol (114605-75-3)

Guidance literature:

With boron trichloride; In dichloromethane; at -10 ℃; for 0.25h;

upstream raw materials:

2,3-dimethoxyphenol

6-bromo-2,3-dimethoxyphenyl toluene-p-sulphonate

methyl 2,3,4-trimethoxybenzoate

2-hydroxy-3,4-dimethoxybenzoic acid

Downstream raw materials:

2-(benzyloxy)-1-bromo-3,4-dimethoxybenzene

2-(2-(benzyloxy)-3,4-dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

methyl 5-amino-4-(2-(benzyloxy)-3,4-dimethoxyphenyl)-3-methyl-6-(5,6,8-trimethoxyquinolin-2-yl)picolinate

(±)-methyl 5-amino-4-(2-(benzyloxy)-5-bromo-3,4-dimethoxyphenyl)-6-(7-bromo-6-methoxy-5,8-dioxo-5,8-dihydroquinolin-2-yl)-3-methylpicolinate

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