Pyrido[2,3-c]pyridazine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo- , monohydrochloride

Base Information

Chemical Name:Pyrido[2,3-c]pyridazine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo- , monohydrochloride
CAS No.:114610-00-3
Molecular Formula:C₁₈H₁₅F₂N₅O₃*ClH
Molecular Weight:423.807
Hs Code.:

Pyrido[2,3-c]pyridazine-3-carboxylic acid,
7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-
, monohydrochloride

Synonyms:

Suppliers and Price of Pyrido[2,3-c]pyridazine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo- , monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Pyrido[2,3-c]pyridazine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo- , monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Pyrido[2,3-c]pyridazine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo- , monohydrochloride

There total 5 articles about Pyrido[2,3-c]pyridazine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo- , monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 114610-20-7
7-(3-Acetylamino-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid ethyl ester

: 114610-00-3
7-(3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid; hydrochloride

Guidance literature:: With hydrogenchloride; for 5h; Heating;
DOI:10.1248/cpb.38.3359

Reference yield:

: 96568-04-6
ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate

: 114610-00-3
7-(3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaNO₂, 20percent HCl, 2) NaOAc / 1) H₂O, 2) EtOH, CHCl₃

2: 95 percent / potassium tert-butoxide / dioxane / 1 h / Ambient temperature

3: 87 percent / Et₃N / acetonitrile / 1 h / Ambient temperature

4: 98 percent / 20percent aq. HCl / 5 h / Heating

With hydrogenchloride; potassium tert-butylate; sodium acetate; triethylamine; sodium nitrite; In 1,4-dioxane; acetonitrile;
DOI:10.1248/cpb.38.3359

Reference yield:

: 125558-70-5
ethyl 7-chloro-6-fluoro-1-(p-fluorophenyl)-4(1H)-oxopyrido<2,3-c>pyridazine-3-carboxylate

: 114610-00-3
7-(3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / Et₃N / acetonitrile / 1 h / Ambient temperature

2: 98 percent / 20percent aq. HCl / 5 h / Heating

With hydrogenchloride; triethylamine; In acetonitrile;
DOI:10.1248/cpb.38.3359