Pyrido[2,3-c]pyridazine-3-carboxylic acid, 7-(4-acetyl-1-piperazinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester

Base Information

Chemical Name:Pyrido[2,3-c]pyridazine-3-carboxylic acid, 7-(4-acetyl-1-piperazinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester
CAS No.:114610-21-8
Molecular Formula:C22H21F2N5O4
Molecular Weight:457.437
Hs Code.:
Mol file:114610-21-8.mol

Synonyms:

Suppliers and Price of Pyrido[2,3-c]pyridazine-3-carboxylic acid, 7-(4-acetyl-1-piperazinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Pyrido[2,3-c]pyridazine-3-carboxylic acid, 7-(4-acetyl-1-piperazinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Pyrido[2,3-c]pyridazine-3-carboxylic acid, 7-(4-acetyl-1-piperazinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester

There total 4 articles about Pyrido[2,3-c]pyridazine-3-carboxylic acid, 7-(4-acetyl-1-piperazinyl)-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 13889-98-0
N-acetylpiperidine

: 125558-70-5
ethyl 7-chloro-6-fluoro-1-(p-fluorophenyl)-4(1H)-oxopyrido<2,3-c>pyridazine-3-carboxylate

: 114610-21-8
7-(4-Acetyl-piperazin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; In acetonitrile; for 1h; Ambient temperature;
DOI:10.1248/cpb.38.3359

Reference yield:

: 96568-04-6
ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate

: 114610-21-8
7-(4-Acetyl-piperazin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaNO₂, 20percent HCl, 2) NaOAc / 1) H₂O, 2) EtOH, CHCl₃

2: 95 percent / potassium tert-butoxide / dioxane / 1 h / Ambient temperature

3: 82 percent / Et₃N / acetonitrile / 1 h / Ambient temperature

With hydrogenchloride; potassium tert-butylate; sodium acetate; triethylamine; sodium nitrite; In 1,4-dioxane; acetonitrile;
DOI:10.1248/cpb.38.3359

Reference yield:

: 114610-19-4
ethyl (2,6-dichloro-5-fluoronicotinoyl)-2-<2-(p-fluorophenyl)hydrazono>acetate

: 114610-21-8
7-(4-Acetyl-piperazin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyrido[2,3-c]pyridazine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / potassium tert-butoxide / dioxane / 1 h / Ambient temperature

2: 82 percent / Et₃N / acetonitrile / 1 h / Ambient temperature

With potassium tert-butylate; triethylamine; In 1,4-dioxane; acetonitrile;
DOI:10.1248/cpb.38.3359