Hydrazinecarboxylic acid, [1-(2-methylphenyl)ethylidene]-, ethyl ester, (E)-

Base Information

• Chemical Name: Hydrazinecarboxylic acid, [1-(2-methylphenyl)ethylidene]-, ethyl ester, (E)-
• CAS No.: 114666-00-1
• Molecular Formula: C12H16N2O2
• Molecular Weight: 220.271
• Mol file: 114666-00-1.mol

Synonyms:

Chemical Property of Hydrazinecarboxylic acid, [1-(2-methylphenyl)ethylidene]-, ethyl ester, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Hydrazinecarboxylic acid, [1-(2-methylphenyl)ethylidene]-, ethyl ester, (E)-

There total 1 articles about Hydrazinecarboxylic acid, [1-(2-methylphenyl)ethylidene]-, ethyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

ethylhydrazine carboxylate (4114-31-2) + 2-Methylacetophenone (577-16-2,122382-54-1) → 2-methylacetophenone-ethoxycarbonylhydrazone (114666-00-1)

Guidance literature:

With acetic acid; In ethanol; water; at 20 ℃; for 2h;

DOI:10.1021/jo052329e

Reference yield: 41.0%

2-methylacetophenone-ethoxycarbonylhydrazone (114666-00-1) + oxalic acid diethyl ester (95-92-1) → ethyl 5-o-tolyl-1H-pyrazole-3-carboxylate

Guidance literature:

2-methylacetophenone-ethoxycarbonylhydrazone; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h;

oxalic acid diethyl ester; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 16h;

With toluene-4-sulfonic acid; In toluene; for 10h; Further stages.; Heating;

DOI:10.1016/j.tetlet.2007.03.093

Reference yield: 24.0%

2-methylacetophenone-ethoxycarbonylhydrazone (114666-00-1) + 1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → 2-(o-tolyl)-3,4,4a,5-tetrahydrooxazolo[3,4-b]pyridazin-7-one

Guidance literature:

2-methylacetophenone-ethoxycarbonylhydrazone; With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; for 1.33333h;

1,2-Epoxy-3-bromopropane; In tetrahydrofuran; at -78 - 20 ℃; for 16h;

DOI:10.1021/jo052329e

upstream raw materials:

ethylhydrazine carboxylate

2-Methylacetophenone