Thiopyrano(2,3-b)indole-9-acetamide, 2,3,4,9-tetrahydro-N,N-diethyl-4-((methylamino)methyl)-, monohydrochloride

Base Information

Chemical Name:Thiopyrano(2,3-b)indole-9-acetamide, 2,3,4,9-tetrahydro-N,N-diethyl-4-((methylamino)methyl)-, monohydrochloride
CAS No.:73426-15-0
Molecular Formula:C₁₉H₂₇N₃OS*ClH
Molecular Weight:381.97
Hs Code.:
DSSTox Substance ID:DTXSID10994183

Synonyms:73426-15-0;Thiopyrano(2,3-b)indole-9-acetamide, 2,3,4,9-tetrahydro-N,N-diethyl-4-((methylamino)methyl)-, monohydrochloride;C19H27N3OS.ClH;DTXSID10994183;LS-153261;2-[4-(2-Aminoethyl)-3,4-dihydrothiopyrano[2,3-b]indol-9(2H)-yl]-N,N-diethylacetamide--hydrogen chloride (1/1)

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Thiopyrano(2,3-b)indole-9-acetamide, 2,3,4,9-tetrahydro-N,N-diethyl-4-((methylamino)methyl)-, monohydrochloride

Chemical Property:

Vapor Pressure:3.3E-11mmHg at 25°C
Boiling Point:527.3°Cat760mmHg
Flash Point:272.7°C
Density:g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:381.1641614
Heavy Atom Count:25
Complexity:429

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)C(=O)CN1C2=CC=CC=C2C3=C1SCCC3CCN.Cl

Technology Process of Thiopyrano(2,3-b)indole-9-acetamide, 2,3,4,9-tetrahydro-N,N-diethyl-4-((methylamino)methyl)-, monohydrochloride

There total 3 articles about Thiopyrano(2,3-b)indole-9-acetamide, 2,3,4,9-tetrahydro-N,N-diethyl-4-((methylamino)methyl)-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (9-Diethylcarbamoylmethyl-2,3,4,9-tetrahydro-thiopyrano[2,3-b]indol-4-ylmethyl)-methyl-carbamic acid tert-butyl ester

: 73426-15-0
N,N-Diethyl-2-(4-methylaminomethyl-3,4-dihydro-2H-thiopyrano[2,3-b]indol-9-yl)-acetamide; hydrochloride

Guidance literature:: With hydrogenchloride; trifluoroacetic acid; In dichloromethane; for 2h; Yield given;
DOI:10.1248/cpb.32.877

Reference yield:

: 73425-49-7
4-aminomethyl-2,3,4,9-tetrahydrothiopyrano<2,3-b>indole

: 73426-15-0
N,N-Diethyl-2-(4-methylaminomethyl-3,4-dihydro-2H-thiopyrano[2,3-b]indol-9-yl)-acetamide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / Et₃N / tetrahydrofuran / 1 h / Ambient temperature

2: 1) 50 percent NaH / 1.) oil, DMF, RT, 1 h; 2.) DMF, oil

3: 1) CF₃COOH; 2) HCl / CH₂Cl₂ / 2 h

With hydrogenchloride; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.32.877

Reference yield:

: 73425-25-9
4-(N-tert-butoxycarbonyl-N-methylaminomethyl)-2,3,4,9-tetrahydrothiopyrano<2,3-b>indole

: 73426-15-0
N,N-Diethyl-2-(4-methylaminomethyl-3,4-dihydro-2H-thiopyrano[2,3-b]indol-9-yl)-acetamide; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1) 50 percent NaH / 1.) oil, DMF, RT, 1 h; 2.) DMF, oil

2: 1) CF₃COOH; 2) HCl / CH₂Cl₂ / 2 h

With hydrogenchloride; sodium hydride; trifluoroacetic acid; In dichloromethane;
DOI:10.1248/cpb.32.877